Sugi Predict

Sugi Predict / Compounds / SCHEMBL22494969

SCHEMBL22494969

SCHEMBL22494969

Nc1nc2cc(Br)ccc2cc1C=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BACE1 P56817 2/20 0.50
▸ PABPC1 P11940 1/20 0.43
▸ ERN1 O75460 2/20 0.42
▸ ALDH1A1 P00352 3/20 0.41
▸ HTT P42858 3/20 0.40
▸ KDM4E B2RXH2 2/20 0.40
▸ GAA P10253 1/20 0.40
▸ TYMS P04818 1/20 0.38
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ MAPT P10636 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ CYP2A6 P11509 2/20 0.37
▸ TLR8 Q9NR97 1/20 0.35
▸ ADRB2 P07550 1/20 0.35
▸ F2 P00734 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ CHRM2 P08172 1/20 0.34
▸ HTR1A P08908 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL790844 0.88 BACE1 (0.50) BACE1PABPC1ERN1ALDH1A1HTT
SCHEMBL378904 0.79 ALDH1A1 (0.66) BACE1PABPC1ERN1ALDH1A1HTT
SCHEMBL807146 0.77 TLR8 (0.55) ALDH1A1HTTKDM4EGAAMEN1
SCHEMBL22743051 0.76 BACE1 (0.59) BACE1PABPC1ALDH1A1HTTKDM4E
SCHEMBL22798793 0.76 ALDH1A1 (0.42) BACE1ERN1ALDH1A1HTTKDM4E
SCHEMBL29523306 0.73 TERT (0.58) ALDH1A1HTTKDM4EGAAMEN1
SCHEMBL11728816 0.73 PABPC1 (0.61) BACE1PABPC1ALDH1A1HTTKDM4E
SCHEMBL21090245 0.73 BACE1 (0.55) BACE1PABPC1ERN1ALDH1A1HTT
SCHEMBL18572030 0.73 BACE1 (0.55) BACE1PABPC1ALDH1A1HTTKDM4E
SCHEMBL21129799 0.73 BACE1 (0.55) BACE1PABPC1ALDH1A1HTTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220112194-A1 COMPOUNDS TARGETING PRMT5 ALIGOS THERAPEUTICS, INC. 2022-04-14 — — US disclosed
CN-114072407-A Compounds targeting PRMT5 阿里戈斯治疗公司 2022-02-18 — — CN disclosed
US-20220048922-A1 COMPOUNDS TARGETING PRMT5 ALIGOS THERAPEUTICS, INC. 2022-02-17 — — US disclosed
EP-3947388-A1 COMPOUNDS TARGETING PRMT5 Aligos Therapeutics, Inc. (US) 2022-02-09 — — EP disclosed
US-11198699-B2 Compounds targeting PRMT5 ALIGOS THERAPEUTICS, INC. (US) 2021-12-14 — — US disclosed
US-20200317686-A1 COMPOUNDS TARGETING PRMT5 ALIGOS THERAPEUTICS, INC. 2020-10-08 — — US disclosed
WO-2020205867-A1 COMPOUNDS TARGETING PRMT5 ALIGOS THERAPEUTICS, INC. (US) 2020-10-08 — — WO disclosed
WO-2020205867-A1 COMPOUNDS TARGETING PRMT5 ALIGOS THERAPEUTICS, INC. (US) 2020-10-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11198699-B2 Compounds targeting PRMT5 PRMT5, PRMT1, PRMT6 BACE1 2330/4885PABPC1 857/4885ERN1 1043/4885
US-20220112194-A1 COMPOUNDS TARGETING PRMT5 PRMT5, PRMT1, PRMT6 BACE1 2330/4885PABPC1 857/4885ERN1 1043/4885
US-20200317686-A1 COMPOUNDS TARGETING PRMT5 PRMT5, PRMT1, PRMT6 BACE1 2330/4885PABPC1 857/4885ERN1 1043/4885
US-20220048922-A1 COMPOUNDS TARGETING PRMT5 PRMT5, PRMT1, PRMT6 BACE1 2330/4885PABPC1 857/4885ERN1 1043/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.