Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.63 |
| ▸ | CA1 | P00915 | 4/20 | 0.63 |
| ▸ | ICMT | O60725 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GRN | P28799 | 2/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247559 | 0.89 | ALDH1A1 (0.58) | CA2CA1KMT2ASMN1; SMN2MRGPRX4 | |
| SCHEMBL5260684 | 0.87 | CA2 (0.70) | CA2CA1KMT2AMMP2MMP9 | |
| SCHEMBL5260686 | 0.87 | CA2 (0.70) | CA2CA1KMT2AMMP2MMP9 | |
| SCHEMBL2246061 | 0.86 | CA2 (0.69) | CA2CA1KMT2AMMP2MMP9 | |
| SCHEMBL2245325 | 0.86 | CA2 (0.69) | CA2CA1KMT2AMMP2MMP9 | |
| SCHEMBL2249549 | 0.84 | MMP12 (0.60) | CA2CA1ICMTMMP2MMP9 | |
| SCHEMBL27517605 | 0.84 | ALDH1A1 (0.57) | CA2CA1ICMTGRNSORT1 | |
| SCHEMBL2251677 | 0.82 | GPR132 (0.55) | CA2CA1PARP10MRGPRX4 | |
| SCHEMBL5999343 | 0.82 | MMP2 (0.52) | MMP2MMP9ADAM17PARP10SMN1; SMN2 | |
| SCHEMBL2247497 | 0.82 | CA2 (0.44) | CA2CA1ICMTMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |