Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | LPL | P06858 | 4/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
| ▸ | CA9 | Q16790 | 3/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27157750 | 0.81 | ROCK1 (0.36) | ROCK1LPLLIPGJAK2 | |
| SCHEMBL6127173 | 0.81 | LPL (0.41) | ROCK1LPLLIPGP2RX7CA1 | |
| SCHEMBL21493489 | 0.77 | KIF11 (0.39) | ROCK1LPLLIPGBACE1P2RX7 | |
| SCHEMBL1477653 | 0.77 | ROCK1 (0.37) | ROCK1LPLLIPGJAK2 | |
| SCHEMBL28347176 | 0.76 | ROCK1 (0.42) | ROCK1LPLLIPG | |
| SCHEMBL14778585 | 0.75 | ROCK1 (0.38) | ROCK1LPLLIPGBACE1JAK2 | |
| SCHEMBL17233424 | 0.74 | ROCK1 (0.34) | ROCK1LPLLIPG | |
| SCHEMBL25118557 | 0.73 | LIPG (0.43) | ROCK1LPLLIPGBACE1P2RX7 | |
| SCHEMBL15726606 | 0.73 | LPL (0.36) | LPLLIPGBACE1P2RX7CA1 | |
| SCHEMBL483144 | 0.73 | CASP1 (0.45) | ROCK1LPLLIPGBACE1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113544129-A | Tricyclic compound preparation method and application thereof in medicine field | 上海华汇拓医药科技有限公司 | 2021-10-22 | — | — | CN | disclosed |
| WO-2020200284-A1 | PREPARATION METHOD FOR TRICYCLIC COMPOUND AND USE OF SAME IN FIELD OF MEDICINE | 上海华汇拓医药科技有限公司 | 2020-10-08 | — | — | WO | disclosed |