Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8A | O60658 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16176222 | 0.78 | — | — | |
| SCHEMBL31087047 | 0.76 | MAOB (0.39) | — | |
| SCHEMBL23301438 | 0.76 | GRIN1 (0.32) | — | |
| SCHEMBL22428384 | 0.75 | ACACB (0.33) | — | |
| SCHEMBL22342459 | 0.74 | — | — | |
| SCHEMBL22452423 | 0.74 | GRM5 (0.38) | — | |
| SCHEMBL17394954 | 0.74 | NAAA (0.44) | — | |
| SCHEMBL17395038 | 0.74 | ACACB (0.30) | — | |
| SCHEMBL355741 | 0.73 | RXRA (0.39) | — | |
| SCHEMBL31168015 | 0.72 | PDE8A (0.36) | PDE8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4744661-A2 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2026-05-20 | — | — | EP | disclosed |
| EP-4298092-B1 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2025-11-26 | — | — | EP | disclosed |
| EP-3947358-B1 | PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2025-06-18 | — | — | EP | disclosed |
| US-12281095-B2 | Pesticidally active diazine-amide compounds | SYNGENTA CROP PROTECTION AG (CH) | 2025-04-22 | — | — | US | disclosed |
| CN-113631549-B | Pesticidally active diazine-amide compounds | 先正达农作物保护股份公司 | 2025-01-17 | — | — | CN | disclosed |
| US-20240025883-A1 | PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-25 | — | — | US | disclosed |
| US-20240025883-A1 | PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-25 | — | — | US | disclosed |
| US-20240025883-A1 | PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-25 | — | — | US | disclosed |
| EP-4298092-A1 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-01-03 | — | — | EP | disclosed |
| CN-116829550-A | Pyrimidine-2-ylsulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |
| US-20220169629-A1 | PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2022-06-02 | — | — | US | disclosed |
| US-20220169629-A1 | PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2022-06-02 | — | — | US | disclosed |
| EP-3953343-A1 | PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS | Syngenta Crop Protection AG (CH) | 2022-02-16 | — | — | EP | disclosed |
| EP-3947358-A1 | PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS | Syngenta Crop Protection AG (CH) | 2022-02-09 | — | — | EP | disclosed |
| CN-113677672-A | Pesticidally active diazine-amide compounds | 先正达农作物保护股份公司 | 2021-11-19 | — | — | CN | disclosed |
| CN-113631549-A | Pesticidally active diazine-amide compounds | 先正达农作物保护股份公司 | 2021-11-09 | — | — | CN | disclosed |
| WO-2020208036-A1 | PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2020-10-15 | — | — | WO | disclosed |
| WO-2020208036-A1 | PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2020-10-15 | — | — | WO | disclosed |
| WO-2020201079-A1 | PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2020-10-08 | — | — | WO | disclosed |
| WO-2020201079-A1 | PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2020-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025883-A1 | PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | GPR17, GPR27, GPR119 | PDE8A 2302/4885 |
| US-12281095-B2 | Pesticidally active diazine-amide compounds | DDT, ACHE, NIT2 | PDE8A 641/4885 |
| US-20220169629-A1 | PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS | DDT, ACHE, NIT2 | PDE8A 500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.