Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22499584 | 0.86 | CA12 (0.47) | PKMPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL24506847 | 0.85 | ALDH1A1 (0.56) | PKMPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29384364 | 0.85 | ALDH1A1 (0.56) | PKMPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL22499562 | 0.84 | MAPT (0.63) | PKMPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29382007 | 0.84 | MAPT (0.63) | PKMPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL10536600 | 0.84 | KMT2A (0.59) | PKMPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL13059466 | 0.83 | MAPT (0.49) | PKMPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL22499583 | 0.82 | MAPT (0.57) | PKMPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29384824 | 0.82 | MAPT (0.57) | PKMPOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL22499593 | 0.82 | MAPT (0.57) | PKMPOLBMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174259-A | Modulators of intracellular chloride concentration | 意大利学院科技基金会 | 2022-03-11 | — | — | CN | claimed |
| EP-3947345-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | Fondazione Istituto Italiano di Tecnologia (IT) | 2022-02-09 | — | — | EP | claimed |
| WO-2020202072-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2020-10-08 | — | — | WO | claimed |
| US-20220184008-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA (IT) | 2022-06-16 | — | — | US | disclosed |
| CN-114174259-A | Modulators of intracellular chloride concentration | 意大利学院科技基金会 | 2022-03-11 | — | — | CN | disclosed |
| EP-3947345-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | Fondazione Istituto Italiano di Tecnologia (IT) | 2022-02-09 | — | — | EP | disclosed |
| WO-2020202072-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2020-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220184008-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | SLC6A1, SLC6A13, SLC6A11 | PKM 969/4885POLB 4307/4885MAPT 956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.