SCHEMBL225016

SCHEMBL225016

Oc1ccccc1OC(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.50
CA1 P00915 1/20 0.50
TP53 P04637 1/20 0.50
TSHR P16473 1/20 0.50
MAPT P10636 3/20 0.46
GAA P10253 3/20 0.46
LMNA P02545 2/20 0.46
JAK2 O60674 1/20 0.46
RAB9A P51151 2/20 0.42
MEN1 O00255 1/20 0.42
HTT P42858 1/20 0.42
KMT2A Q03164 1/20 0.42
APP P05067 2/20 0.41
RXRA P19793 1/20 0.41
RXRB P28702 1/20 0.41
RXRG P48443 1/20 0.41
ALDH1A1 P00352 3/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
KDM4E B2RXH2 1/20 0.41
NPC1 O15118 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29715057 1.00 CA2 (0.50) CA2CA1TP53TSHRMAPT
Formaldehyde SCHEMBL28314099 0.94 CA1 (0.45) CA2CA1TP53TSHRMAPT
SCHEMBL9588707 0.87 CA1 (0.43) CA2CA1TP53TSHRMAPT
SCHEMBL28785709 0.84 ALDH1A1 (0.52) CA2CA1TP53TSHRMAPT
SCHEMBL27470653 0.83 ALDH1A1 (0.46) CA2CA1TP53TSHRMAPT
SCHEMBL2092887 0.82 CA2 (0.46) CA2CA1TP53TSHRMAPT
SCHEMBL11002065 0.82 TSHR (0.52) CA2CA1TP53TSHRMAPT
SCHEMBL4654446 0.82 RXRA (0.47) CA2CA1MAPTGAARXRA
SCHEMBL2094188 0.80 MAPT (0.39) CA2CA1TP53TSHRMAPT
SCHEMBL6442084 0.80 CA2 (0.45) CA2CA1TP53TSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1583 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12187911-B2 Method for preparing water-soluble acrylic-modified phenolic-modified epoxy resin, water-soluble acrylic-modified phenolic-modified epoxy resin prepared thereby, and aqueous coating composition comprising same SAMHWA PAINTS INDUSTRIES CO., LTD. (KR) 2025-01-07 US claimed
EP-4392414-A1 INHIBITORS OF NLRP3 PTC Therapeutics, Inc. (US) 2024-07-03 EP claimed
US-20240158396-A1 COMPOUNDS FOR INHIBITING NLRP3 AND USES THEREOF VENTUS THERAPEUTICS U S INC (US) 2024-05-16 US claimed
EP-4363406-A1 NLRP3 INFLAMMASOME INHIBITORS Astrazeneca AB (SE) 2024-05-08 EP claimed
US-20240117213-A1 METHOD FOR PREPARING WATER-SOLUBLE ACRYLIC-MODIFIED PHENOLIC-MODIFIED EPOXY RESIN, WATER-SOLUBLE ACRYLIC-MODIFIED PHENOLIC-MODIFIED EPOXY RESIN PREPARED THEREBY, AND AQUEOUS COATING COMPOSITION COMPRISING SAME SAMHWA PAINTS INDUSTRIES CO., LTD. (KR) 2024-04-11 US claimed
WO-2023028534-A1 INHIBITORS OF NLRP3 PTC THERAPEUTICS, INC. (US) 2023-03-02 WO claimed
WO-2023275366-A1 NLRP3 INFLAMMASOME INHIBITORS ASTRAZENECA AB (SE) 2023-01-05 WO claimed
CN-111481989-B Production trifluoromethyl (oxygen) formula filtration equipment is adjusted with multilayer to phenol 内蒙古大中实业化工有限公司 2022-03-04 CN claimed
WO-2021075800-A1 METHOD FOR PREPARING WATER-SOLUBLE ACRYLIC-MODIFIED PHENOLIC-MODIFIED EPOXY RESIN, WATER-SOLUBLE ACRYLIC-MODIFIED PHENOLIC-MODIFIED EPOXY RESIN PREPARED THEREBY, AND AQUEOUS COATING COMPOSITION COMPRISING SAME 삼화페인트공업주식회사 2021-04-22 WO claimed
CN-106565428-B A kind of aphthacene organic semiconducting materials and preparation method thereof 北京大学深圳研究生院 2019-11-26 CN claimed
CN-1041927-C Dihalotriazolopyrimidine derivatives as fungicides SHELL INT RESEARCH (NL) 1999-02-03 CN claimed
CN-1193320-A 1,3-oxa(thio) zine derivatives BAYER AG (DE) 1998-09-16 CN claimed
CN-1184405-A Insecticidal N -(substituted arylmethyl) -4 -[bis (substituted phenyl or pyridyl) methyl] piperidines FMC CORP (US) 1998-06-10 CN claimed
CN-1153779-A 2-(4-pyrazoloxy-pyrimidin-5-yl) acetic acid derivatives SANDOZ LTD (CH) 1997-07-09 CN claimed
CN-1147193-A Insecticidal N-(substd. Arylmethyl)-4-[bis(substd. phenyl) methyl] piperidines FMC CORP (US) 1997-04-09 CN claimed
CN-1139434-A Diazabicyclic neurokinin antagonists PFIZER (US) 1997-01-01 CN claimed
CN-1119015-A Dihalotriazolopyrimidine derivatives as fungicides SHELL INT RESEARCH (NL) 1996-03-20 CN claimed
CN-1075144-A Triazolopyrimidine derivatives SHELL INT RESEARCH (NL) 1993-08-11 CN claimed
EP-0054149-B1 TRIFLUOROMETHOXYPHENYL-(DI)THIOPHOSPHORIC-ACID ESTERS, PROCESS FOR PREPARING THEM AND THEIR USE AS PESTICIDES BASF Aktiengesellschaft (DE) 1984-05-16 EP claimed
EP-0054149-A1 Trifluoromethoxyphenyl-(di)thiophosphoric-acid esters, process for preparing them and their use as pesticides BASF Aktiengesellschaft (DE) 1982-06-23 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158396-A1 COMPOUNDS FOR INHIBITING NLRP3 AND USES THEREOF NLRP3, NLRP1, PYCARD CA2 4559/4885CA1 4796/4885TP53 1053/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.