Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.68 |
| ▸ | IGLV6-57 | P01721 | 6/20 | 0.68 |
| ▸ | HPGD | P15428 | 6/20 | 0.68 |
| ▸ | GLA | P06280 | 5/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.68 |
| ▸ | CASP1 | P29466 | 3/20 | 0.68 |
| ▸ | CASP7 | P55210 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22501697 | 0.89 | IGLV6-57 (0.78) | ALDH1A1IGLV6-57HPGDGLAHSD17B10 | |
| SCHEMBL22501590 | 0.88 | IGLV6-57 (0.69) | ALDH1A1IGLV6-57HPGDGLAHSD17B10 | |
| SCHEMBL67108 | 0.81 | ALDH1A1 (1.00) | ALDH1A1IGLV6-57HPGDGLAHSD17B10 | |
| SCHEMBL29362472 | 0.81 | ALDH1A1 (1.00) | ALDH1A1IGLV6-57HPGDGLAHSD17B10 | |
| SCHEMBL384286 | 0.81 | ALDH1A1 (1.00) | ALDH1A1IGLV6-57HPGDGLAHSD17B10 | |
| SCHEMBL11059919 | 0.79 | IGLV6-57 (0.89) | ALDH1A1IGLV6-57HPGDGLAHSD17B10 | |
| SCHEMBL3689704 | 0.77 | ALDH1A1 (0.66) | ALDH1A1IGLV6-57HPGDGLAHSD17B10 | |
| SCHEMBL24590058 | 0.77 | ALDH1A1 (0.70) | ALDH1A1IGLV6-57HPGDGLAHSD17B10 | |
| SCHEMBL22501632 | 0.77 | IGLV6-57 (1.00) | ALDH1A1IGLV6-57HPGDGLAHSD17B10 | |
| SCHEMBL1752667 | 0.77 | ALDH1A1 (0.70) | ALDH1A1IGLV6-57HPGDGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11945806-B2 | Stabilization of amyloidogenic immunoglobulin light chains | THE SCRIPPS RESEARCH INSTITUTE | 2024-04-02 | — | — | US | disclosed |
| US-20220204485-A1 | STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS | THE SCRIPPS RESEARCH INSTITUTE | 2022-06-30 | — | — | US | disclosed |
| US-20220204485-A1 | STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS | THE SCRIPPS RESEARCH INSTITUTE | 2022-06-30 | — | — | US | disclosed |
| EP-3946604-A1 | BENZOPYRANE AND IMIDAZOLE DERIVATIVES USEFUL FOR THE STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS | The Scripps Research Institute (US) | 2022-02-09 | — | — | EP | disclosed |
| WO-2020205683-A1 | BENZOPYRANE AND IMIDAZOLE DERIVATIVES USEFUL FOR THE STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220204485-A1 | STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS | TTR, MAP1LC3B, SAAL1 | ALDH1A1 2072/4885IGLV6-57 7/4885HPGD 3113/4885 |
| US-11945806-B2 | Stabilization of amyloidogenic immunoglobulin light chains | TTR, MAP1LC3B, SAAL1 | ALDH1A1 2072/4885IGLV6-57 7/4885HPGD 3113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.