Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 17/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2256178 | 0.78 | P2RX7 (0.42) | P2RX7 | |
| SCHEMBL20103445 | 0.75 | P2RX7 (0.52) | P2RX7MEN1GAACASP6KMT2A | |
| SCHEMBL3654179 | 0.75 | P2RX7 (0.52) | P2RX7MEN1GAACASP6KMT2A | |
| SCHEMBL20103179 | 0.72 | HTR1A (0.48) | P2RX7 | |
| SCHEMBL20205261 | 0.69 | P2RX7 (0.45) | P2RX7MEN1GAACASP6KMT2A | |
| SCHEMBL20103153 | 0.69 | P2RX7 (0.45) | P2RX7MEN1GAACASP6KMT2A | |
| SCHEMBL3651018 | 0.68 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2248234 | 0.68 | ALDH1A1 (0.45) | P2RX7MEN1GAAKMT2A | |
| SCHEMBL2253286 | 0.68 | BPTF (0.44) | — | |
| SCHEMBL4328191 | 0.68 | P2RX7 (0.47) | P2RX7MEN1GAACASP6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354413-B2 | Quinolin-4-one and 4-oxodihydrocinnoline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP) | Istituto di Ricerche di Biologia Molecolare P. Angeletti, S.R.L. (IT) | 2013-01-15 | — | — | US | disclosed |
| US-20110207720-A1 | QUINOLIN-4-ONE AND 4-OXODIHYRDOCINNOLINE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. (IT) | 2011-08-25 | — | — | US | disclosed |
| EP-2193121-A1 | QUINOLIN-4-ONE AND 4-OXODIHYDROCINNOLINE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009027730-A1 | QUINOLIN-4-ONE AND 4-OXODIHYDROCINNOLINE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207720-A1 | QUINOLIN-4-ONE AND 4-OXODIHYRDOCINNOLINE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | PARP1, PARP2, PARP11 | P2RX7 902/4885MEN1 2511/4885GAA 1856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.