Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 5/20 | 0.57 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | AKT2 | P31751 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.52 |
| ▸ | BLK | P51451 | 1/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8611330 | 1.00 | SMPD1 (0.57) | SMPD1CHUKDAPK3JAK2ROCK2 | |
| SCHEMBL8974027 | 0.80 | SMPD1 (0.58) | SMPD1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8587456 | 0.79 | THRA (0.50) | SMPD1CHUKDAPK3JAK2ROCK2 | |
| SCHEMBL279706 | 0.79 | HTR3E (0.59) | PDE4ALMNAMAPTMAPK1 | |
| SCHEMBL8587460 | 0.78 | PRSS1 (0.50) | SMPD1CHUKDAPK3JAK2ROCK2 | |
| SCHEMBL24305898 | 0.78 | SMPD1 (0.56) | SMPD1PDE4BTHRATHRBC5 | |
| SCHEMBL9698395 | 0.78 | SMPD1 (0.59) | SMPD1PDE4BCNR2THRATHRB | |
| SCHEMBL8974122 | 0.78 | SMPD1 (0.56) | SMPD1CHUKDAPK3JAK2ROCK2 | |
| SCHEMBL7994834 | 0.77 | SMPD1 (0.54) | SMPD1PDE4BTHRATHRBPDE3B | |
| SCHEMBL13352265 | 0.77 | FDPS (0.67) | SMPD1PDE4BCNR2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020205501-A1 | COMPLEMENT MODULATORS AND RELATED METHODS | RA PHARMACEUTICALS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |