Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Demecarium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 15/20 | 0.54 |
| ▸ | BCHE | P06276 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demecarium SCHEMBL29425243 | 0.87 | ACHE (0.70) | ACHEBCHELMNAMEN1KMT2A | |
| Demecarium SCHEMBL34283 | 0.87 | ACHE (0.70) | ACHEBCHELMNAMEN1KMT2A | |
| Demecarium SCHEMBL61421 | 0.86 | ACHE (0.69) | ACHEBCHELMNAMEN1KMT2A | |
| Demecarium SCHEMBL31649032 | 0.86 | ACHE (0.69) | ACHEBCHELMNAMEN1KMT2A | |
| SCHEMBL12043598 | 0.73 | ACHE (0.73) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL29618009 | 0.72 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL41128 | 0.72 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Demecarium SCHEMBL28300620 | 0.71 | ACHE (0.46) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL8026154 | 0.70 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL34419 | 0.70 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9180045-B2 | Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device | MATI THERAPEUTICS INC. (US) | 2015-11-10 | — | — | US | disclosed |
| US-20110202020-A1 | TREATMENT MEDIUM DELIVERY DEVICE AND METHODS FOR DELIVERY OF SUCH TREATMENT MEDIUMS TO THE EYE USING SUCH A DELIVERY DEVICE | QLT INC. (CA) | 2011-08-18 | — | — | US | disclosed |