Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Demecarium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 17/20 | 0.70 |
| ▸ | BCHE | P06276 | 4/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demecarium SCHEMBL29425243 | 1.00 | ACHE (0.70) | ACHEBCHELMNAMEN1KMT2A | |
| Demecarium SCHEMBL61421 | 0.99 | ACHE (0.69) | ACHEBCHELMNAMEN1KMT2A | |
| Demecarium SCHEMBL31649032 | 0.99 | ACHE (0.69) | ACHEBCHELMNAMEN1KMT2A | |
| Demecarium SCHEMBL2253116 | 0.87 | ACHE (0.54) | ACHEBCHELMNAMEN1KMT2A | |
| SCHEMBL12043598 | 0.85 | ACHE (0.73) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL29618009 | 0.83 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL41128 | 0.83 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL34419 | 0.81 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL8026154 | 0.81 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A | |
| Neostigmine SCHEMBL29603805 | 0.81 | ACHE (1.00) | ACHEBCHELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3111 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250186415-A1 | EXTENDED-RELEASE PHARMACEUTICAL COMPOSITIONS FOR TREATING EYE CONDITIONS | FIFTH THIRD BANK, NATIONAL ASSOCIATION, AS AGENT | 2025-06-12 | — | — | US | claimed |
| WO-2025067458-A1 | OPHTHALMIC PHARMACEUTICAL COMPOSITION AND USE THEREOF | 苏州普乐康医药科技有限公司 | 2025-04-03 | — | — | WO | claimed |
| EP-4489858-A1 | EXTENDED-RELEASE PHARMACEUTICAL COMPOSITIONS FOR TREATING EYE CONDITIONS | Harrow IP, LLC (US) | 2025-01-15 | — | — | EP | claimed |
| EP-3413872-B1 | NON-INVASIVE OCULAR DRUG DELIVERY INSERT TECHNOLOGY | UNIV DE COIMBRA (PT) | 2024-10-02 | — | — | EP | claimed |
| US-20240261291-A1 | Ophthalmic Compositions and/or Methods for Presbyopia, Mydriasis and/or Ocular Discomfort Management | BRIEN HOLDEN VISION INSTITUTE LTD (AU) | 2024-08-08 | — | — | US | claimed |
| WO-2024163315-A2 | DERIVATIZED COLLAGEN-HYALURONIC ACID BASED IMPLANTS FOR SUSTAINED DELIVERY OF OPHTHALMIC DRUGS | DEVORE DALE (US) | 2024-08-08 | — | — | WO | claimed |
| US-20240252446-A1 | DERIVATIZED COLLAGEN-HYALURONIC ACID BASED IMPLANTS FOR SUSTAINED DELIVERY OF OPHTHALMIC DRUGS | SUSTAINED DRUG DELIVERY LLC | 2024-08-01 | — | — | US | claimed |
| US-20240139166-A1 | OPHTHALMIC COMPOSITIONS FOR PRESBYOPIA | Sydnexis, Inc. | 2024-05-02 | — | — | US | claimed |
| US-11884779-B2 | Ionically modified silicones, compositions, and medical devices formed therefrom | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2024-01-30 | — | — | US | claimed |
| EP-4288049-A1 | OPHTHALMIC COMPOSITIONS FOR PRESBYOPIA | Sydnexis, Inc. (US) | 2023-12-13 | — | — | EP | claimed |
| WO-1985002755-A1 | METHOD AND COMPOSITION FOR TREATING PEDICULOSIS | SOFT SHEEN PRODUCTS, INC. (US) | 1985-07-04 | — | — | WO | claimed |
| EP-0126684-A2 | Drug delivery system utilizing thermosetting gels | MERCK & CO. INC. (US) | 1984-11-28 | — | — | EP | claimed |
| US-4439427-A | Method and composition for treating pediculosis | SOFT SHEEN PRODUCTS, INC. (US) | 1984-03-27 | — | — | US | claimed |
| US-4186184-A | Selective administration of drug with ocular therapeutic system | ALZA CORPORATION (US) | 1980-01-29 | — | — | US | claimed |
| US-4115544-A | DRUG PARTICLES MIXED WITH RELEASE RATE-CONTROLLING HOMOPOLYMER | ALZA CORPORATION (US) | 1978-09-19 | — | — | US | claimed |
| US-4014335-A | Ocular drug delivery device | ALZA CORPORATION (US) | 1977-03-29 | — | — | US | claimed |
| US-4014334-A | Laminated osmotic system for dispensing beneficial agent | ALZA CORPORATION (US) | 1977-03-29 | — | — | US | claimed |
| US-4008719-A | Osmotic system having laminar arrangement for programming delivery of active agent | ALZA CORPORATION (US) | 1977-02-22 | — | — | US | claimed |
| US-4001388-A | POLYESTERS | ALZA CORPORATION (US) | 1977-01-04 | — | — | US | claimed |
| US-3962414-A | Structured bioerodible drug delivery device | ALZA CORPORATION (US) | 1976-06-08 | — | — | US | claimed |