Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CD38 | P28907 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27077029 | 0.81 | ALOX15 (0.41) | P2RX7ALDH1A1MAPTGAAHSP90AA1 | |
| SCHEMBL30697188 | 0.81 | ALOX15 (0.41) | P2RX7ALDH1A1MAPTGAAHSP90AA1 | |
| SCHEMBL22695513 | 0.81 | LMNA (0.42) | P2RX7ALDH1A1NPSR1HSP90AA1HSP90AB1 | |
| SCHEMBL29882592 | 0.79 | HSP90AA1 (0.42) | P2RX7ALDH1A1NPSR1HSP90AA1HSP90AB1 | |
| SCHEMBL18839634 | 0.79 | HSP90AA1 (0.42) | P2RX7ALDH1A1NPSR1HSP90AA1HSP90AB1 | |
| SCHEMBL2342015 | 0.79 | NQO2 (0.46) | P2RX7ALDH1A1MAPTHSP90AA1HSP90AB1 | |
| SCHEMBL22540911 | 0.78 | P2RX7 (0.54) | P2RX7ALDH1A1NPSR1MAPTHTT | |
| SCHEMBL23580468 | 0.75 | KDM4E (0.47) | ALDH1A1NPSR1MAPTGAATP53 | |
| SCHEMBL29882458 | 0.75 | KDM4E (0.47) | ALDH1A1NPSR1MAPTGAATP53 | |
| SCHEMBL2552127 | 0.75 | P2RX7 (1.00) | P2RX7ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020210508-A1 | 3-SUBSTITUTED PIPERIDINE COMPOUNDS FOR CBL-B INHIBITION, AND USE OF A CBL-B INHIBITOR IN COMBINATION WITH A CANCER VACCINE AND/OR ONCOLYTIC VIRUS | NURIX THERAPEUTICS, INC. (US) | 2020-10-15 | — | — | WO | disclosed |