Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159251 | 0.90 | PREP (0.59) | PREPSIGMAR1ALDH1A1OPRK1LMNA | |
| SCHEMBL11263011 | 0.90 | PREP (0.59) | PREPSIGMAR1ALDH1A1OPRK1LMNA | |
| SCHEMBL27795955 | 0.86 | PREP (0.56) | PREPSIGMAR1ALDH1A1OPRK1LMNA | |
| SCHEMBL8253758 | 0.84 | PREP (0.60) | PREPALDH1A1OPRK1LMNASMN1; SMN2 | |
| SCHEMBL8750837 | 0.84 | PREP (0.60) | PREPSIGMAR1ALDH1A1OPRK1LMNA | |
| SCHEMBL2586953 | 0.84 | L3MBTL1 (0.61) | PREPALDH1A1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL7683566 | 0.84 | GAA (0.54) | PREPSIGMAR1ALDH1A1OPRK1LMNA | |
| SCHEMBL8249773 | 0.83 | PREP (0.59) | PREPALDH1A1OPRK1LMNASMN1; SMN2 | |
| SCHEMBL5873672 | 0.82 | GAA (0.55) | PREPSIGMAR1ALDH1A1OPRK1LMNA | |
| SCHEMBL22548206 | 0.82 | ALDH1A1 (0.61) | PREPSIGMAR1ALDH1A1OPRK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020210662-A1 | SMALL MOLECULES FOR CANCER THERAPY THAT REDUCE THE EXPRESSION OF TRANSCRIPTION FACTORS KLF5 AND EGR-1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-10-15 | — | — | WO | disclosed |