Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19717001 | 0.78 | APLNR (0.53) | APLNRGABRA5 | |
| SCHEMBL19716497 | 0.78 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CSMN1; SMN2APLNR | |
| SCHEMBL29658558 | 0.78 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CSMN1; SMN2APLNR | |
| SCHEMBL9649808 | 0.78 | ADRB2 (0.37) | ADRA2AADRA2BADRA2CCA12CA1 | |
| SCHEMBL20644139 | 0.77 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CCA12CA1 | |
| SCHEMBL2068072 | 0.75 | HTT (0.43) | ADRA2AADRA2BADRA2CSMN1; SMN2L3MBTL1 | |
| SCHEMBL22556951 | 0.75 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CCA12CA1 | |
| SCHEMBL15466329 | 0.74 | PANK3 (0.40) | LMNAL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL19716796 | 0.74 | CACNA1I (0.44) | CA1CA2NNMTKDM4E | |
| SCHEMBL22557408 | 0.74 | ALDH1A1 (0.34) | ADRA2AADRA2BADRA2CCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956322-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020211839-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-10-22 | — | — | WO | disclosed |