Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 13/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30753606 | 1.00 | RPS6KA5 (0.47) | RPS6KA5PIN1MAPTFGFR1PDE10A | |
| SCHEMBL22556978 | 0.79 | RPS6KA5 (0.52) | RPS6KA5MAPTSMN1; SMN2POLB | |
| SCHEMBL30753600 | 0.79 | RPS6KA5 (0.52) | RPS6KA5MAPTSMN1; SMN2POLB | |
| SCHEMBL19533517 | 0.73 | PIN1 (0.42) | RPS6KA5PIN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL27335197 | 0.68 | PDE10A (0.56) | PIN1MAPTPDE10ASMN1; SMN2KDM4E | |
| SCHEMBL19533520 | 0.66 | FGFR1 (0.54) | RPS6KA5MAPTFGFR1SMN1; SMN2MEN1 | |
| SCHEMBL31511393 | 0.66 | PIN1 (0.49) | PIN1MAPTPDE10AKDM4EMEN1 | |
| SCHEMBL12813490 | 0.65 | PIN1 (0.56) | PIN1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27253708 | 0.65 | RPS6KA5 (0.57) | RPS6KA5PIN1MAPTSMN1; SMN2 | |
| SCHEMBL28910296 | 0.65 | ALDH1A1 (0.44) | MAPTFGFR1PDE10ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956322-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020211839-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-10-22 | — | — | WO | disclosed |