SCHEMBL22562263

SCHEMBL22562263

FC(F)(F)c1ccc2c3ccccc3n(-c3cc(-c4cccc(-c5ccccc5-c5ccccc5)n4)cc(-n4c5ccccc5c5ccc(C(F)(F)F)cc54)c3C(F)(F)F)c2c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.40
MAT2A P31153 2/20 0.36
PTGER1 P34995 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
NPC1 O15118 2/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
ATM Q13315 1/20 0.34
LMNA P02545 2/20 0.33
ALDH1A1 P00352 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
MAPT P10636 1/20 0.33
MAOB P27338 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
ENPP1 P22413 1/20 0.33
CTSS P25774 1/20 0.33
DHODH Q02127 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562264 0.94 KIF11 (0.35) KIF11PTGER1CYP1A2CYP2C9CYP2C19
SCHEMBL22562477 0.93 KIF11 (0.44) KIF11MAT2APTGER1CYP1A2CYP2C9
SCHEMBL22562478 0.89 MAT2A (0.41) KIF11MAT2APTGER1CYP1A2CYP2C9
SCHEMBL22562510 0.88 CTSS (0.39) KIF11MAT2APTGER1CYP1A2CYP2C9
SCHEMBL22562476 0.86 KIF11 (0.39) KIF11PTGER1CYP1A2CYP2C9CYP2C19
SCHEMBL22562244 0.85 KIF11 (0.39) KIF11MAT2APTGER1CYP1A2CYP2C9
SCHEMBL22562381 0.83 MEN1 (0.35) KIF11NPC1MEN1KMT2AATM
SCHEMBL22562602 0.83 MEN1 (0.37) KIF11MAT2ANPC1MEN1KMT2A
SCHEMBL22562353 0.82 RAB9A (0.39) MAT2APTGER1CYP1A2CYP2C9CYP2C19
SCHEMBL22562413 0.81 KIF11 (0.41) KIF11MAT2APTGER1CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed