SCHEMBL22562571

SCHEMBL22562571

N#Cc1ccc(-c2ccc3c4ccc(-c5ccc(C#N)cc5C#N)cc4n(-c4cc(C(F)(F)F)cc(-n5c6cc(-c7ccc(C#N)cc7C#N)ccc6c6ccc(-c7ccc(C#N)cc7C#N)cc65)c4-c4cccc(-c5ccccc5)n4)c3c2)c(C#N)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 2/20 0.37
PDK2 Q15119 2/20 0.36
CTSS P25774 1/20 0.35
ALOX5AP P20292 1/20 0.35
FEN1 P39748 1/20 0.35
GABRA1 P14867 1/20 0.34
GABRG2 P18507 1/20 0.34
GABRB3 P28472 1/20 0.34
GABRA5 P31644 1/20 0.34
GABRA3 P34903 1/20 0.34
ALDH1A3 P47895 1/20 0.33
MAT2A P31153 1/20 0.33
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
SCN9A Q15858 4/20 0.32
JAK2 O60674 1/20 0.32
PRKD3 O94806 1/20 0.32
ABL1 P00519 1/20 0.32
EGFR P00533 1/20 0.32
ERBB2 P04626 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562480 0.97 XDH (0.36) XDHPDK2CTSSALOX5APFEN1
SCHEMBL22562577 0.93 XDH (0.37) XDHPDK2CTSSALOX5APFEN1
SCHEMBL22562481 0.92 XDH (0.36) XDHPDK2CTSSALOX5APFEN1
SCHEMBL22562272 0.91 ALDH1A3 (0.36) PDK2GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562574 0.90 CTSS (0.41) PDK2CTSSGABRA1GABRG2GABRB3
SCHEMBL22562396 0.88 GABRG2 (0.38) XDHCTSSALOX5APFEN1GABRA1
SCHEMBL22562267 0.88 ALDH1A3 (0.34) PDK2GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562572 0.87 CTSS (0.39) PDK2CTSSGABRA1GABRG2GABRB3
SCHEMBL22562486 0.86 SCN9A (0.36) XDHPDK2GABRA1GABRG2GABRB3
SCHEMBL22562485 0.86 CTSS (0.38) XDHPDK2CTSSGABRA1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed