SCHEMBL22562574

SCHEMBL22562574

N#Cc1ccc2c3ccc(C#N)cc3n(-c3cc(C(F)(F)F)cc(-n4c5cc(C#N)ccc5c5ccc(C#N)cc54)c3-c3cccc(-c4ccccc4)n3)c2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.41
JAK2 O60674 1/20 0.38
PRKD3 O94806 1/20 0.38
ABL1 P00519 1/20 0.38
EGFR P00533 1/20 0.38
ERBB2 P04626 1/20 0.38
LCK P06239 1/20 0.38
CDK1 P06493 1/20 0.38
CSF1R P07333 1/20 0.38
LYN P07948 1/20 0.38
RET P07949 1/20 0.38
KIT P10721 1/20 0.38
FGFR1 P11362 1/20 0.38
FER P16591 1/20 0.38
FLT1 P17948 1/20 0.38
FGFR3 P22607 1/20 0.38
KDR P35968 1/20 0.38
FLT3 P36888 1/20 0.38
FRK P42685 1/20 0.38
SYK P43405 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562572 0.97 CTSS (0.39) CTSSJAK2PRKD3ABL1EGFR
SCHEMBL22562573 0.91 CTSS (0.39) CTSSJAK2PRKD3ABL1EGFR
SCHEMBL22562440 0.90 ALDH1A3 (0.41) CTSSSYKCLK4MAT2AALDH1A3
SCHEMBL22562485 0.90 CTSS (0.38) CTSSSYKIRAK4MAT2AALDH1A3
SCHEMBL22562571 0.90 XDH (0.37) CTSSJAK2PRKD3ABL1EGFR
SCHEMBL22562479 0.89 ALDH1A3 (0.37) CTSSSYKMAT2AABCB1ABCG2
SCHEMBL22562305 0.87 ALDH1A3 (0.43) CTSSSYKCLK4MAT2AALDH1A3
SCHEMBL22562483 0.87 CTSS (0.39) CTSSSYKMAT2AABCB1ABCG2
SCHEMBL22562405 0.87 MAT2A (0.41) CTSSMAT2AMEN1RAB9AKMT2A
SCHEMBL22562469 0.85 RAB9A (0.38) CTSSMAT2APDK2MEN1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed