Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 3/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22562946 | 0.86 | MAP2K2 (0.39) | MAP2K1KMT2AMEN1KDM4EGAA | |
| SCHEMBL22563163 | 0.86 | HDAC1 (0.40) | NUDT1MAP2K1CNR2KMT2AMEN1 | |
| SCHEMBL22563054 | 0.84 | MAPK14 (0.40) | KDM4EGAAHSD17B10HDAC1RAB9A | |
| SCHEMBL22563085 | 0.83 | PYGL (0.41) | CNR2GAAHDAC1CSF1RHTT | |
| SCHEMBL22562957 | 0.82 | MAP2K1 (0.41) | MAP2K1KMT2AMEN1KDM4EGAA | |
| SCHEMBL22563088 | 0.79 | MAPK14 (0.44) | KMT2AGAAMAPTHTT | |
| SCHEMBL22563010 | 0.73 | HDAC6 (0.37) | HDAC1LMNA | |
| SCHEMBL22562974 | 0.73 | TAS2R14 (0.42) | KMT2AMEN1KDM4EGAAGFER | |
| SCHEMBL22563002 | 0.72 | MAP2K2 (0.41) | MAP2K1KMT2AMEN1KDM4EGAA | |
| SCHEMBL22562958 | 0.71 | JAK1 (0.37) | KMT2AMEN1KDM4EHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725777-A1 | BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | Rottapharm Biotech S.r.l. (IT) | 2020-10-21 | — | — | EP | disclosed |