Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.37 |
| ▸ | TYK2 | P29597 | 4/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | F7 | P08709 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22563186 | 0.86 | JAK1 (0.37) | JAK1TYK2JAK3JAK2HDAC1 | |
| SCHEMBL22563010 | 0.86 | HDAC6 (0.37) | JAK1TYK2JAK3HDAC1HDAC6 | |
| SCHEMBL22563054 | 0.79 | MAPK14 (0.40) | HDAC1KDM4EALDH1A1SIRT2 | |
| SCHEMBL22563034 | 0.76 | HDAC1 (0.37) | JAK1TYK2JAK3JAK2HDAC1 | |
| SCHEMBL22563018 | 0.74 | ACVRL1 (0.39) | KMT2A | |
| SCHEMBL22562946 | 0.72 | MAP2K2 (0.39) | HDAC1KDM4EALDH1A1HDAC6MEN1 | |
| SCHEMBL22562974 | 0.71 | TAS2R14 (0.42) | KDM4EALDH1A1MEN1KMT2ASIRT2 | |
| SCHEMBL22562967 | 0.71 | NUDT1 (0.37) | HDAC1KDM4EMEN1KMT2A | |
| SCHEMBL22562939 | 0.71 | PTGS2 (0.38) | JAK1TYK2JAK3JAK2HDAC1 | |
| SCHEMBL22563088 | 0.69 | MAPK14 (0.44) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725777-A1 | BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | Rottapharm Biotech S.r.l. (IT) | 2020-10-21 | — | — | EP | disclosed |