Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | HPN | P05981 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22563056 | 0.67 | HDAC1 (0.41) | MAPTKDM4ENPC1MEN1KMT2A | |
| SCHEMBL3289894 | 0.66 | HRH3 (0.45) | CA2HTT | |
| SCHEMBL22563013 | 0.66 | MAPK14 (0.41) | KDM4ENPC1GAAGFERMEN1 | |
| SCHEMBL28533240 | 0.64 | BDKRB2 (0.49) | TAS1R3TAS1R1 | |
| SCHEMBL22563037 | 0.63 | RARB (0.47) | MAPTMEN1KMT2A | |
| SCHEMBL8759863 | 0.62 | NR1I2 (0.47) | MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL21078080 | 0.62 | TAS1R3 (0.58) | SMN1; SMN2GAASCN5ASCN2ACA2 | |
| SCHEMBL28863365 | 0.61 | MEN1 (0.53) | MAPTSMN1; SMN2NPC1GAASCN5A | |
| SCHEMBL28836790 | 0.61 | HSD17B10 (0.46) | SMN1; SMN2NPC1CA2MEN1KMT2A | |
| SCHEMBL21711047 | 0.61 | TAS1R3 (0.73) | SMN1; SMN2HTTTAS1R3TAS1R1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725777-A1 | BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | Rottapharm Biotech S.r.l. (IT) | 2020-10-21 | — | — | EP | disclosed |