Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | F2R | P25116 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22562963 | 0.82 | MAPK14 (0.39) | HDAC1HDAC3HDAC2KMT2ANPC1 | |
| SCHEMBL22563017 | 0.72 | HDAC1 (0.37) | HDAC1HDAC3HDAC2NCOR2KDM4E | |
| SCHEMBL22563034 | 0.72 | HDAC1 (0.37) | HDAC1HDAC3HDAC2NCOR2KDM4E | |
| SCHEMBL22562998 | 0.71 | MAPK14 (0.33) | HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL22564663 | 0.69 | HDAC1 (0.34) | HDAC1HDAC3HDAC2NCOR2KDM4E | |
| SCHEMBL22563055 | 0.68 | TBXA2R (0.38) | HDAC1KMT2AMEN1MAPT | |
| SCHEMBL22562973 | 0.67 | MAPT (0.36) | KMT2ANPC1KDM4EMEN1MAPT | |
| SCHEMBL21732183 | 0.63 | OPRM1 (0.42) | — | |
| SCHEMBL28533240 | 0.61 | BDKRB2 (0.49) | LMNAHPGD | |
| SCHEMBL22563037 | 0.60 | RARB (0.47) | KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725777-A1 | BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | Rottapharm Biotech S.r.l. (IT) | 2020-10-21 | — | — | EP | disclosed |