Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.31 |
| ▸ | PLK1 | P53350 | 2/20 | 0.30 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22563043 | 0.86 | ALDH1A1 (0.35) | HDAC1HDAC3HDAC2PLK1PLK3 | |
| SCHEMBL22562963 | 0.80 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11HDAC1 | |
| SCHEMBL22563017 | 0.77 | HDAC1 (0.37) | MAPK14MAPK13MAPK12MAPK11HDAC1 | |
| SCHEMBL22563034 | 0.76 | HDAC1 (0.37) | HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL22563014 | 0.75 | MAPK1 (0.34) | HDAC1 | |
| SCHEMBL22564663 | 0.73 | HDAC1 (0.34) | HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL22563056 | 0.71 | HDAC1 (0.41) | HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL22564672 | 0.70 | HDAC1 (0.35) | HDAC1 | |
| SCHEMBL22564671 | 0.68 | HDAC8 (0.34) | HDAC1HDAC3HDAC2ITGB3NCOR2 | |
| SCHEMBL22562991 | 0.61 | RARB (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725777-A1 | BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | Rottapharm Biotech S.r.l. (IT) | 2020-10-21 | — | — | EP | disclosed |