Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22563056 | 0.82 | HDAC1 (0.41) | HDAC1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL22562998 | 0.80 | MAPK14 (0.33) | MAPK14MAPK13MAPK12MAPK11HDAC1 | |
| SCHEMBL22563055 | 0.74 | TBXA2R (0.38) | HDAC1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL22563033 | 0.72 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11HDAC1 | |
| SCHEMBL22563017 | 0.72 | HDAC1 (0.37) | MAPK14MAPK13MAPK12MAPK11HDAC1 | |
| SCHEMBL22563043 | 0.68 | ALDH1A1 (0.35) | HDAC1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9799041 | 0.66 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL22563034 | 0.66 | HDAC1 (0.37) | HDAC1HDAC3HDAC2ALDH1A1 | |
| SCHEMBL12172229 | 0.63 | NR1I2 (0.47) | KMT2AL3MBTL1 | |
| SCHEMBL27718637 | 0.63 | MAPK13 (0.59) | MAPK14MAPK13MAPK12MAPK11NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725777-A1 | BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | Rottapharm Biotech S.r.l. (IT) | 2020-10-21 | — | — | EP | disclosed |