Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 7/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22562963 | 0.74 | MAPK14 (0.39) | HDAC1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL22563056 | 0.68 | HDAC1 (0.41) | HDAC1KMT2AMEN1MAPT | |
| SCHEMBL22563043 | 0.66 | ALDH1A1 (0.35) | HDAC1KMT2AMEN1NAMPTALDH1A1 | |
| SCHEMBL21783907 | 0.63 | TSHR (0.46) | ALDH1A1 | |
| SCHEMBL28533240 | 0.61 | BDKRB2 (0.49) | ALDH1A1 | |
| SCHEMBL18432620 | 0.61 | CYP2A6 (0.48) | ALDH1A1MAPT | |
| SCHEMBL8131540 | 0.60 | TSHR (0.50) | ALDH1A1 | |
| SCHEMBL22563037 | 0.60 | RARB (0.47) | KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL20303234 | 0.60 | KDM4E (0.54) | KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL19232073 | 0.60 | TSHR (0.49) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725777-A1 | BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | Rottapharm Biotech S.r.l. (IT) | 2020-10-21 | — | — | EP | disclosed |