Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 3/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 2/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.44 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27770739 | 0.83 | LMNA (0.56) | LMNACYP1A2SMN1; SMN2CYP2D6PKM | |
| SCHEMBL16476537 | 0.83 | CYP1A2 (0.56) | LMNACYP1A2SMN1; SMN2CYP2D6PKM | |
| SCHEMBL375857 | 0.83 | CYP1A2 (0.56) | LMNACYP1A2SMN1; SMN2CYP2D6PKM | |
| SCHEMBL10061317 | 0.80 | THRB (0.49) | SMN1; SMN2DPP4MMP12MMP13MMP2 | |
| SCHEMBL15269483 | 0.80 | ADRB2 (0.49) | SMN1; SMN2DPP4MMP12MMP13MMP2 | |
| SCHEMBL15269481 | 0.80 | ADRB2 (0.49) | SMN1; SMN2DPP4MMP12MMP13MMP2 | |
| SCHEMBL15269485 | 0.80 | ADRB2 (0.49) | SMN1; SMN2DPP4MMP12MMP13MMP2 | |
| SCHEMBL28625596 | 0.79 | CA1 (0.58) | LMNACYP1A2SMN1; SMN2CYP2D6PKM | |
| SCHEMBL28625595 | 0.79 | CA1 (0.58) | LMNACYP1A2SMN1; SMN2CYP2D6PKM | |
| Trifluoroacetic Acid SCHEMBL28688144 | 0.76 | LMNA (0.48) | LMNACYP1A2SMN1; SMN2CYP2D6PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994326-B2 | For treatment of various forms of neurodegeneration, including that from stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease | NORTHWESTERN UNIVERSITY (US) | 2011-08-09 | — | — | US | disclosed |