Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.62 |
| ▸ | MMP1 | P03956 | 5/20 | 0.60 |
| ▸ | MMP2 | P08253 | 5/20 | 0.60 |
| ▸ | MMP9 | P14780 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2260339 | 1.00 | KDM1A (0.62) | KDM1AMMP1MMP2MMP9MEN1 | |
| SCHEMBL2266670 | 0.92 | MMP1 (0.64) | KDM1AMMP1MMP2MMP9MEN1 | |
| SCHEMBL2266660 | 0.92 | MMP1 (0.64) | KDM1AMMP1MMP2MMP9MEN1 | |
| SCHEMBL2259537 | 0.90 | KDM1A (0.62) | KDM1AMMP1MMP2MMP9MEN1 | |
| SCHEMBL2259531 | 0.90 | KDM1A (0.62) | KDM1AMMP1MMP2MMP9MEN1 | |
| SCHEMBL2265795 | 0.89 | MMP1 (0.60) | KDM1AMMP1MMP2MMP9MEN1 | |
| SCHEMBL2265790 | 0.89 | MMP1 (0.60) | KDM1AMMP1MMP2MMP9MEN1 | |
| SCHEMBL2265844 | 0.88 | HDAC3 (0.56) | KDM1AMMP1MMP2MMP9MEN1 | |
| SCHEMBL2265838 | 0.88 | HDAC3 (0.56) | KDM1AMMP1MMP2MMP9MEN1 | |
| SCHEMBL2262942 | 0.88 | PKM (0.66) | KDM1AMMP1MMP2MMP9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349982-B1 | ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | CONGENIA S R L (IT) | 2015-08-05 | — | — | EP | claimed |
| US-20110195977-A1 | ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | CONGENIA SRL (IT) | 2011-08-11 | — | — | US | claimed |
| EP-2349982-A1 | ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | Congenia S.r.l. (IT) | 2011-08-03 | — | — | EP | claimed |
| WO-2010049768-A1 | ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | CONGENIA SRL (IT) | 2010-05-06 | — | — | WO | claimed |
| WO-2016144352-A2 | THERAPEUTIC COMPOSITIONS INCLUDING ACRYLAMIDO COMPOUNDS OR PHENYL-SUBSTITUTED MALEIMIDE COMPOUNDS, VARIANTS THEREOF AND METHODS OF USING THE SAME | STEALTH PEPTIDES INTERNATIONAL, INC. (MC) | 2016-09-15 | — | — | WO | disclosed |
| EP-2349982-B1 | ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | CONGENIA S R L (IT) | 2015-08-05 | — | — | EP | disclosed |
| US-8669261-B2 | Acrylomido derivatives useful as inhibitors of the mitochondrial permeability transition | Congenia SLR (IT) | 2014-03-11 | — | — | US | disclosed |
| US-8669261-B2 | Acrylomido derivatives useful as inhibitors of the mitochondrial permeability transition | Congenia SLR (IT) | 2014-03-11 | — | — | US | disclosed |
| US-20130245019-A1 | ACRYLOMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | CONGENIA SRL (IT) | 2013-09-19 | — | — | US | disclosed |
| US-20130245019-A1 | ACRYLOMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | CONGENIA SRL (IT) | 2013-09-19 | — | — | US | disclosed |
| US-8470831-B2 | Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition | Cogenia SRL (IT) | 2013-06-25 | — | — | US | disclosed |
| US-8470831-B2 | Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition | Cogenia SRL (IT) | 2013-06-25 | — | — | US | disclosed |
| US-20110195977-A1 | ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | CONGENIA SRL (IT) | 2011-08-11 | — | — | US | disclosed |
| US-20110195977-A1 | ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | CONGENIA SRL (IT) | 2011-08-11 | — | — | US | disclosed |
| EP-2349982-A1 | ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | Congenia S.r.l. (IT) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010049768-A1 | ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | CONGENIA SRL (IT) | 2010-05-06 | — | — | WO | disclosed |
| EP-2179984-A1 | Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition | Congenia S.r.l. (IT) | 2010-04-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195977-A1 | ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | AIFM1, TFAM, NDUFAB1 | KDM1A 4515/4885MMP1 816/4885MMP2 2115/4885 |
| US-20130245019-A1 | ACRYLOMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION | AIFM1, TFAM, NDUFAB1 | KDM1A 4588/4885MMP1 733/4885MMP2 1623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.