SCHEMBL22607115

SCHEMBL22607115

Nc1cccc(-c2cc(C(F)(F)F)c(-c3cccc(N)c3C(F)(F)F)cc2C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.44
GAA P10253 2/20 0.44
GLA P06280 1/20 0.44
POLB P06746 1/20 0.44
MAPK1 P28482 1/20 0.35
MPL P40238 3/20 0.35
HSD11B1 P28845 1/20 0.35
ALDH1A1 P00352 2/20 0.34
PDE3B Q13370 1/20 0.34
PDE3A Q14432 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
PDK2 Q15119 1/20 0.34
CFTR P13569 4/20 0.34
BACE1 P56817 2/20 0.33
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
PTGS1 P23219 1/20 0.33
CES1 P23141 1/20 0.33
ACHE P22303 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2202986 0.88 ALDH1A1 (0.43) TSHRGAAGLAPOLBMAPK1
SCHEMBL19031762 0.86 TSHR (0.67) TSHRGAAGLAPOLBMAPK1
SCHEMBL3788313 0.82 ALDH1A1 (0.56) TSHRGAAPOLBMAPK1HSD11B1
SCHEMBL790403 0.77 HSD11B1 (0.40) TSHRGAAGLAPOLBMAPK1
SCHEMBL5794355 0.76 TSHR (0.43) TSHRGAAPOLBMAPK1ALDH1A1
SCHEMBL16340864 0.76 HSD11B1 (0.44) TSHRGAAGLAPOLBMPL
SCHEMBL22607118 0.75 MPL (0.38) TSHRPOLBMAPK1MPLHSD11B1
SCHEMBL3793637 0.74 ALDH1A1 (0.56) TSHRGAAMAPK1ALDH1A1L3MBTL1
SCHEMBL3785346 0.74 MAP4K4 (0.46) TSHRGAAGLAPOLBMAPK1
SCHEMBL3790566 0.73 KIF11 (0.45) TSHRGAAGLAPOLBMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220325045-A1 POLYMERS FOR USE IN ELECTRONIC DEVICES U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2022-10-13 US disclosed
WO-2020219411-A1 POLYMERS FOR USE IN ELECTRONIC DEVICES DUPONT ELECTRONICS, INC. (US) 2020-10-29 WO disclosed