SCHEMBL3785346

SCHEMBL3785346

Nc1cccc(-c2cccc(N)c2C(F)(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP4K4 O95819 3/20 0.46
TSHR P16473 2/20 0.46
MAPK1 P28482 1/20 0.46
MAOA P21397 1/20 0.44
CYP3A4 P08684 2/20 0.38
CASP1 P29466 1/20 0.38
RECQL P46063 1/20 0.38
GLA P06280 1/20 0.37
POLB P06746 1/20 0.37
GAA P10253 1/20 0.37
MEN1 O00255 1/20 0.37
PSIP1 O75475 1/20 0.37
AXL P30530 1/20 0.37
MKNK1 Q9BUB5 1/20 0.37
MKNK2 Q9HBH9 1/20 0.37
KIT P10721 1/20 0.37
SYK P43405 1/20 0.37
MAPT P10636 2/20 0.36
ALDH1A1 P00352 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30648132 0.88 TSHR (0.44) MAP4K4TSHRMAPK1MAOACYP3A4
SCHEMBL28686237 0.84 MAP4K4 (0.45) MAP4K4TSHRMAPK1MAOACYP3A4
SCHEMBL3793637 0.83 ALDH1A1 (0.56) MAP4K4TSHRMAPK1CYP3A4GAA
SCHEMBL3790566 0.81 KIF11 (0.45) TSHRMAPK1CYP3A4GLAPOLB
SCHEMBL2202986 0.80 ALDH1A1 (0.43) TSHRMAPK1CYP3A4CASP1GLA
SCHEMBL9343382 0.79 MAOA (0.39) MAP4K4TSHRMAPK1MAOAGLA
SCHEMBL31607638 0.77 ALDH1A1 (0.62) MAP4K4MAOACYP3A4CASP1RECQL
SCHEMBL2442638 0.77 ALDH1A1 (0.62) MAP4K4MAOACYP3A4CASP1RECQL
SCHEMBL30839741 0.77 ALDH1A1 (0.62) MAP4K4MAOACYP3A4CASP1RECQL
SCHEMBL29636990 0.77 ALDH1A1 (0.62) MAP4K4MAOACYP3A4CASP1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113072702-A Colorless transparent copolymerized polyimide film and preparation method thereof 上海大学(浙江·嘉兴)新兴产业研究院 2021-07-06 CN claimed
CN-116730845-A High-fluorine-content biphenyl diamine, colorless polyimide optical film, and preparation method and application thereof 华南理工大学 2023-09-12 CN disclosed
CN-113072702-A Colorless transparent copolymerized polyimide film and preparation method thereof 上海大学(浙江·嘉兴)新兴产业研究院 2021-07-06 CN disclosed
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2010-04-08 US disclosed
EP-1914221-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-04-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND NISCH, BLVRB, BBOX1 MAP4K4 3704/4885TSHR 1688/4885MAPK1 4726/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.