Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22607224 | 0.88 | DHFR (0.39) | DHFRTNKSTNKS2LIMK1CDK5 | |
| SCHEMBL17697068 | 0.78 | L3MBTL1 (0.42) | TNKSTNKS2LIMK1CDK5CDK5R1 | |
| SCHEMBL12425537 | 0.78 | ALOX5 (0.40) | TNKSTNKS2LIMK1ALOX5PTPN1 | |
| SCHEMBL17945214 | 0.77 | GPR3 (0.41) | DHFRALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL24341485 | 0.77 | ALOX5 (0.42) | TNKSTNKS2ALOX5PTPN1ALDH1A1 | |
| SCHEMBL20650700 | 0.76 | GPR3 (0.43) | DHFRTGFBR1PTPN1ALDH1A1HPGD | |
| SCHEMBL124825 | 0.76 | ALOX5 (0.49) | DHFRALOX5MEN1MAPTRAB9A | |
| SCHEMBL17943954 | 0.76 | ALOX5 (0.45) | DHFRALOX5ALDH1A1HPGDMEN1 | |
| SCHEMBL19628157 | 0.76 | NQO1 (0.36) | DHFRTNKSTNKS2ALOX5PTPN1 | |
| SCHEMBL12425547 | 0.76 | ALOX5 (0.39) | TNKSTNKS2LIMK1ALOX5PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11706982-B2 | Fused polycyclic compound, and preparation method and use thereof | NINGBO LUMILAN ADVANCED MATERIALS CO., LTD. (CN) | 2023-07-18 | — | — | US | disclosed |
| US-11706982-B2 | Fused polycyclic compound, and preparation method and use thereof | NINGBO LUMILAN ADVANCED MATERIALS CO., LTD. (CN) | 2023-07-18 | — | — | US | disclosed |
| US-20200343455-A1 | Fused Polycyclic Compound, and Preparation Method and Use Thereof | NINGBO LUMILAN ADVANCED MATERIALS, CO., LTD. (CN) | 2020-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11706982-B2 | Fused polycyclic compound, and preparation method and use thereof | INF2, INTS9, PYM1 | DHFR 349/4885TNKS 2686/4885TNKS2 2754/4885 |
| US-20200343455-A1 | Fused Polycyclic Compound, and Preparation Method and Use Thereof | INF2, INTS9, PYM1 | DHFR 349/4885TNKS 2686/4885TNKS2 2754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.