Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 12/20 | 0.92 |
| ▸ | BCL2 | P10415 | 11/20 | 0.92 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.92 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.92 |
| ▸ | MEN1 | O00255 | 2/20 | 0.92 |
| ▸ | NPC1 | O15118 | 2/20 | 0.92 |
| ▸ | USP2 | O75604 | 2/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.92 |
| ▸ | LMNA | P02545 | 2/20 | 0.92 |
| ▸ | POLB | P06746 | 2/20 | 0.92 |
| ▸ | GAA | P10253 | 2/20 | 0.92 |
| ▸ | MAPT | P10636 | 2/20 | 0.92 |
| ▸ | THRB | P10828 | 2/20 | 0.92 |
| ▸ | HPGD | P15428 | 2/20 | 0.92 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.92 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.92 |
| ▸ | BLM | P54132 | 2/20 | 0.92 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.92 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gossypol SCHEMBL3939 | 0.96 | MCL1 (1.00) | MCL1BCL2AKR1B1KDM4EMEN1 | |
| Gossypol SCHEMBL29798874 | 0.96 | MCL1 (1.00) | MCL1BCL2AKR1B1KDM4EMEN1 | |
| Gossypol SCHEMBL9738017 | 0.96 | MCL1 (1.00) | MCL1BCL2AKR1B1KDM4EMEN1 | |
| Gossypol SCHEMBL30260519 | 0.96 | MCL1 (1.00) | MCL1BCL2AKR1B1KDM4EMEN1 | |
| Gossypol SCHEMBL29355719 | 0.96 | MCL1 (1.00) | MCL1BCL2AKR1B1KDM4EMEN1 | |
| Gossypol SCHEMBL23014699 | 0.94 | MCL1 (0.97) | MCL1BCL2AKR1B1KDM4EMEN1 | |
| Gossypol SCHEMBL28855396 | 0.94 | MCL1 (0.97) | MCL1BCL2AKR1B1KDM4EMEN1 | |
| Gossypol SCHEMBL27755741 | 0.94 | MCL1 (0.97) | MCL1BCL2AKR1B1KDM4EMEN1 | |
| Gossypol SCHEMBL28166062 | 0.94 | MCL1 (0.97) | MCL1BCL2AKR1B1KDM4EMEN1 | |
| Gossypol SCHEMBL27542391 | 0.94 | MCL1 (0.97) | MCL1BCL2AKR1B1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101327201-A | Gossypol or liquid preparation of analogue thereof and preparation method and use thereof | SHANGHAI INST OF PLANNED PAREN (CN) | 2008-12-24 | — | — | CN | claimed |
| US-20200369618-A1 | ASYMMETRIC DERIVATIVES OF POLYPHENOLS OF THE DINAPHTHALINE SERIES, PROCESS OF PREPARING AND USE THEREOF | Nearmedic International Limited (CY) | 2020-11-26 | — | — | US | disclosed |
| EP-3731933-A1 | ASYMMETRIC DERIVATIVES OF POLYPHENOLS OF THE DINAPHTHALINE SERIES, PROCESS OF PREPARING AND USE THEREOF | Nearmedic International Limited (CY) | 2020-11-04 | — | — | EP | disclosed |
| CN-102584560-B | Synthesis method of compounds of 5-benzoyl-1, 4-naphthaquinone with similar gossypol effect | UNIV SOUTHEAST | 2013-11-27 | — | — | CN | disclosed |
| CN-101327201-B | Gossypol or liquid preparation of analogue thereof and preparation method and use thereof | SHANGHAI INST PLANNED PARENTHOOD RES | 2013-02-13 | — | — | CN | disclosed |
| CN-102584560-A | Synthesis method of compounds of 5-benzoyl-1, 4-naphthaquinone with similar gossypol effect | UNIV SOUTHEAST | 2012-07-18 | — | — | CN | disclosed |
| CN-101327201-A | Gossypol or liquid preparation of analogue thereof and preparation method and use thereof | SHANGHAI INST OF PLANNED PAREN (CN) | 2008-12-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200369618-A1 | ASYMMETRIC DERIVATIVES OF POLYPHENOLS OF THE DINAPHTHALINE SERIES, PROCESS OF PREPARING AND USE THEREOF | DNM2, DNM1, MAVS | MCL1 3671/4885BCL2 3675/4885AKR1B1 1151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.