Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21069311 | 1.00 | POLB (0.35) | POLBALDH1A1MAPK1GAAMAPT | |
| SCHEMBL21070171 | 0.83 | CASP1 (0.38) | POLBMEN1KMT2AHTTAKT1 | |
| SCHEMBL20436626 | 0.82 | TRPA1 (0.38) | MAPTTSHR | |
| SCHEMBL5855412 | 0.81 | TDP1 (0.39) | POLBGAAMAPTTSHR | |
| SCHEMBL5855399 | 0.81 | TDP1 (0.39) | POLBGAAMAPTTSHR | |
| SCHEMBL21069376 | 0.78 | ALDH1A1 (0.41) | POLBALDH1A1MAPK1MAPTTSHR | |
| SCHEMBL16414460 | 0.73 | MMP12 (0.38) | POLBGAAMAPTTSHR | |
| SCHEMBL16414506 | 0.73 | MMP12 (0.38) | POLBGAAMAPTTSHR | |
| SCHEMBL16414459 | 0.73 | MMP12 (0.38) | POLBGAAMAPTTSHR | |
| SCHEMBL25439640 | 0.73 | POLB (0.51) | POLBALDH1A1MAPK1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |