SCHEMBL22610141

SCHEMBL22610141

O=C(O)C1CC1CCCc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MFN2 O95140 1/20 0.60
GRM2 Q14416 3/20 0.52
GRM3 Q14832 3/20 0.52
FFAR4 Q5NUL3 10/20 0.51
ALDH1A1 P00352 1/20 0.48
KMT2A Q03164 1/20 0.48
HDAC3 O15379 1/20 0.47
MAPK1 P28482 1/20 0.47
ADRA1A P35348 1/20 0.47
HDAC4 P56524 1/20 0.47
SLC6A3 Q01959 1/20 0.47
HDAC1 Q13547 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
HDAC9 Q9UKV0 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26108166 1.00 MFN2 (0.60) MFN2GRM2GRM3FFAR4ALDH1A1
SCHEMBL31728258 0.89 FFAR4 (0.60) FFAR4
SCHEMBL1841593 0.89 FFAR4 (0.60) FFAR4
SCHEMBL23533312 0.84 GRM2 (0.55) MFN2GRM2GRM3FFAR4ALDH1A1
SCHEMBL11243352 0.81 MFN2 (0.46) MFN2GRM2GRM3ALDH1A1KMT2A
SCHEMBL11243363 0.81 MFN2 (0.46) MFN2GRM2GRM3ALDH1A1KMT2A
SCHEMBL11251088 0.81 MFN2 (0.46) MFN2GRM2GRM3ALDH1A1KMT2A
SCHEMBL6267268 0.80 EPHX2 (0.47) MFN2FFAR4HDAC3HDAC4HDAC1
SCHEMBL27028429 0.79 MFN2 (0.51) MFN2GRM2GRM3FFAR4ALDH1A1
SCHEMBL30645025 0.79 MFN2 (0.51) MFN2GRM2GRM3FFAR4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250099404-A1 TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF MITOCHONDRIA IN MOTION, INC. (US) 2025-03-27 US disclosed
US-20250091983-A1 CYCLOPENTANE AND CYCLOHEXANE VARIANTS OF 6-PHENYLHEXANAMIDE MITOFUSIN ACTIVATORS AND METHODS FOR USE THEREOF MITOCHONDRIA EMOTION, INC. (US) 2025-03-20 US disclosed
US-20240199534-A1 CYCLOPROPANE ANALOGUES OF N-(TRANS-4-HYDROXYCYCLOHEXYL)-6-PHENYLHEXANAMIDE AND RELATED COMPOUNDS DORN, GERALD W., II, DR. 2024-06-20 US disclosed
EP-4308540-A1 CYCLOPROPANE ANALOGUES OF N-(TRANS-4-HYDROXYCYCLOHEXYL)-6-PHENYLHEXANAMIDE AND RELATED COMPOUNDS Mitochondria Emotion, Inc. (US) 2024-01-24 EP disclosed
CN-117377652-A Cyclopropane analogues of N- (trans-4-hydroxycyclohexyl) -6-phenylhexanamide and related compounds 线粒体情感状态公司 2024-01-09 CN disclosed
WO-2023014828-A2 CYCLOPENTANE AND CYCLOHEXANE VARIANTS OF 6-PHENYLHEXANAMIDE MITOFUSIN ACTIVATORS AND METHODS FOR USE THEREOF MITOCHONDRIA EMOTION, INC. (US) 2023-02-09 WO disclosed
WO-2022198139-A1 CYCLOPROPANE ANALOGUES OF N-(TRANS-4-HYDROXYCYCLOHEXYL)-6-PHENYLHEXANAMIDE AND RELATED COMPOUNDS MITOCHONDRIA EMOTION, INC. (US) 2022-09-22 WO disclosed
US-20210251925-A1 TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF MITOCHONDRIA EMOTION, INC. (US) 2021-08-19 US disclosed
US-11083699-B2 Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof MITOCHONDRIA EMOTION, INC. (US) 2021-08-10 US disclosed
US-20200345668-A1 TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF MITOCHONDRIA EMOTION, INC. (US) 2020-11-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200345668-A1 TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF MFN2, TFB2M, HADHA MFN2 1/4885GRM2 1967/4885GRM3 3829/4885
US-11083699-B2 Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof MFN2, TFB2M, HADHA MFN2 1/4885GRM2 1967/4885GRM3 3829/4885
US-20240199534-A1 CYCLOPROPANE ANALOGUES OF N-(TRANS-4-HYDROXYCYCLOHEXYL)-6-PHENYLHEXANAMIDE AND RELATED COMPOUNDS HAGH, HADHA, NLN MFN2 135/4885GRM2 2705/4885GRM3 3247/4885
US-20210251925-A1 TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF MFN2, TFB2M, HADHA MFN2 1/4885GRM2 1967/4885GRM3 3829/4885
US-20250099404-A1 TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF MFN2, TFB2M, HADHA MFN2 1/4885GRM2 1967/4885GRM3 3829/4885
US-20250091983-A1 CYCLOPENTANE AND CYCLOHEXANE VARIANTS OF 6-PHENYLHEXANAMIDE MITOFUSIN ACTIVATORS AND METHODS FOR USE THEREOF COQ8A, PDF, HAGH MFN2 6/4885GRM2 3830/4885GRM3 4349/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.