Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 | P28472 | 9/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.40 |
| ▸ | MARS1 | P56192 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2260858 | 0.90 | GABRA2 (0.43) | GABRB3GABRA2GABRB2MAPK1MAP2K4 | |
| SCHEMBL2261831 | 0.87 | GABRB3 (0.42) | GABRB3GABRA2GABRB2CYP1A2MEN1 | |
| SCHEMBL549152 | 0.85 | GABRA2 (0.58) | GABRB3GABRA2GABRB2MAPK1MAP2K4 | |
| SCHEMBL1550851 | 0.84 | GABRA2 (0.43) | GABRB3GABRA2GABRB2MAPK1MAP2K4 | |
| SCHEMBL2260964 | 0.76 | POLB (0.44) | GABRB3GABRA2GABRB2MEN1KMT2A | |
| SCHEMBL1551160 | 0.76 | RAB9A (0.42) | GABRB3GABRA2GABRB2MEN1KMT2A | |
| SCHEMBL18321922 | 0.76 | GABRA2 (0.46) | GABRB3GABRA2GABRB2MARS1 | |
| SCHEMBL20249062 | 0.74 | GABRA2 (0.44) | GABRB3GABRA2GABRB2MARS1MAPT | |
| SCHEMBL548243 | 0.71 | GABRA2 (0.47) | GABRA2GABRB2MAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL548181 | 0.70 | POLB (0.59) | GABRB3GABRA2GABRB2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201656-A1 | NOVEL DIPHENYL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2011-08-18 | — | — | US | claimed |
| CN-102123992-A | Novel diphenyl 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors | NEUROSEARCH AS | 2011-07-13 | — | — | CN | claimed |
| US-20110201656-A1 | NOVEL DIPHENYL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2011-08-18 | — | — | US | disclosed |
| CN-102123992-A | Novel diphenyl 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors | NEUROSEARCH AS | 2011-07-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201656-A1 | NOVEL DIPHENYL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA3, CHRNB3, CHRNA5 | GABRB3 168/4885GABRA2 331/4885GABRB2 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.