SCHEMBL22632540

SCHEMBL22632540

Nc1cc(Cl)c(Oc2cc(C3CCC3)c(Cl)nn2)c(Cl)c1

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 16/20 0.37
ALOX5AP P20292 14/20 0.34
MAPT P10636 1/20 0.32
THRB P10828 2/20 0.31
HSD11B1 P28845 1/20 0.30
THRA P10827 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29414843 1.00 FEN1 (0.37) FEN1ALOX5APMAPTTHRBHSD11B1
SCHEMBL23421620 0.97 FEN1 (0.35) FEN1ALOX5APMAPTTHRBHSD11B1
SCHEMBL29986640 0.97 FEN1 (0.35) FEN1ALOX5APMAPTTHRBHSD11B1
SCHEMBL29987261 0.96 THRB (0.35) FEN1ALOX5APMAPTTHRBHSD11B1
SCHEMBL31524123 0.94 THRA (0.33) FEN1MAPTTHRBTHRA
SCHEMBL21749432 0.94 THRA (0.33) FEN1MAPTTHRBTHRA
SCHEMBL30297354 0.85 THRA (0.35) FEN1ALOX5APTHRBTHRA
SCHEMBL24032513 0.84 MAPT (0.33) MAPT
SCHEMBL28632953 0.83 THRB (0.33) MAPTTHRBHSD11B1THRA
SCHEMBL23260087 0.83 MAPT (0.32) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304561-A1 MODULATORS OF THR-BETA AND METHODS OF USE THEREOF ALIGOS THERAPEUTICS, INC. (US) 2025-10-02 US disclosed
EP-4523692-A2 MODULATORS OF THR-SS AND METHODS OF USE THEREOF Aligos Therapeutics, Inc. (US) 2025-03-19 EP disclosed
EP-3965884-B1 MODULATORS OF THR-BETA WITH A DIOXO-1,2,4-TRIAZYL HEAD GROUP ALIGOS THERAPEUTICS INC (US) 2025-01-15 EP disclosed
US-12180192-B2 Modulators of THR-β and methods of use thereof ALIGOS THERAPEUTICS, INC. (US) 2024-12-31 US disclosed
US-20230167091-A1 SUBSTITUTED PYRIDAZINONE COMPOUND AND USE THEREOF Shandong First Medical University & Shandong Academy Of Medical Sciences (CN) 2023-06-01 US disclosed
US-20230167091-A1 SUBSTITUTED PYRIDAZINONE COMPOUND AND USE THEREOF Shandong First Medical University & Shandong Academy Of Medical Sciences (CN) 2023-06-01 US disclosed
WO-2022127779-A1 SUBSTITUTED PYRIDAZINONE COMPOUND AND USE THEREOF 山东第一医科大学(山东省医学科学院) 2022-06-23 WO disclosed
EP-3965884-A1 MODULATORS OF THR-BETA AND METHODS OF USE THEREOF Aligos Therapeutics, Inc. (US) 2022-03-16 EP disclosed
US-20210355112-A1 MODULATORS OF THR-BETA AND METHODS OF USE THEREOF ALIGOS THERAPEUTICS, INC. (US) 2021-11-18 US disclosed
US-11091467-B2 Modulators of THR-β and methods of use thereof ALIGOS THERAPEUTICS, INC. (US) 2021-08-17 US disclosed
WO-2021104288-A1 1,2,4-TRIAZINE-3,5-DIONE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 昆药集团股份有限公司 2021-06-03 WO disclosed
WO-2021104288-A1 1,2,4-TRIAZINE-3,5-DIONE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 昆药集团股份有限公司 2021-06-03 WO disclosed
US-20200354345-A1 MODULATORS OF THR-BETA AND METHODS OF USE THEREOF ALIGOS THERAPEUTICS, INC. (US) 2020-11-12 US disclosed
WO-2020227549-A1 MODULATORS OF THR-β AND METHODS OF USE THEREOF ALIGOS THERAPEUTICS, INC. (US) 2020-11-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210355112-A1 MODULATORS OF THR-BETA AND METHODS OF USE THEREOF THRB, THRA, TRHR FEN1 3867/4885ALOX5AP 4526/4885MAPT 1399/4885
US-20250304561-A1 MODULATORS OF THR-BETA AND METHODS OF USE THEREOF THRB, THRA, TRHR FEN1 3760/4885ALOX5AP 4544/4885MAPT 1383/4885
US-20200354345-A1 MODULATORS OF THR-BETA AND METHODS OF USE THEREOF THRB, THRA, TRHR FEN1 3867/4885ALOX5AP 4526/4885MAPT 1399/4885
US-12180192-B2 Modulators of THR-β and methods of use thereof THRB, THRA, TRHR FEN1 4099/4885ALOX5AP 4545/4885MAPT 1243/4885
US-20230167091-A1 SUBSTITUTED PYRIDAZINONE COMPOUND AND USE THEREOF THRB, TPO, TSHR FEN1 3625/4885ALOX5AP 1695/4885MAPT 1274/4885
US-11091467-B2 Modulators of THR-β and methods of use thereof THRB, THRA, TRHR FEN1 4099/4885ALOX5AP 4545/4885MAPT 1243/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.