Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAUR | Q03405 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | GPR3 | P46089 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967704 | 0.76 | CYP3A4 (0.46) | PLAURMAPTNPC1RAB9AHTT | |
| SCHEMBL2338687 | 0.71 | TDP1 (0.38) | PLAURMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2360699 | 0.69 | PLAUR (0.59) | PLAURMAPTSMN1; SMN2RAB9AHTT | |
| SCHEMBL18099793 | 0.68 | KDM4E (0.53) | MAPTSMN1; SMN2NPC1RAB9AMAPK1 | |
| Hydrochloric Acid SCHEMBL22748626 | 0.67 | PLAUR (0.57) | PLAURMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1650848 | 0.67 | PLAUR (0.47) | PLAURMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL11278490 | 0.66 | EGFR (0.46) | PLAURMAPTSMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5336924 | 0.66 | PLAUR (0.46) | PLAURSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL1014701 | 0.64 | GPR3 (0.48) | SMN1; SMN2NPC1RAB9AHTTALDH1A1 | |
| SCHEMBL2693525 | 0.64 | HCAR2 (0.42) | PLAURMAPTALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994160-B2 | Pyridazine compounds as glycogen synthase kinase 3 inhibitors | ABBOTT GMBH & CO. KG (DE) | 2011-08-09 | — | — | US | disclosed |
| US-20090325937-A1 | Pyridazine Compounds as Glycogen Synthase Kinase 3 Inhibitors | ABBOTT GMBH & CO. KG (DE) | 2009-12-31 | — | — | US | disclosed |
| EP-1902055-A1 | PYRIDAZINE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | Abbott GmbH & Co. KG (DE) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007006566-A1 | PYRIDAZINE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325937-A1 | Pyridazine Compounds as Glycogen Synthase Kinase 3 Inhibitors | GSK3B, GSK3A, GYS2 | PLAUR 3790/4885MAPT 2770/4885SMN1; SMN2 2972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.