Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.55 |
| ▸ | GRM8 | O00222 | 2/20 | 0.55 |
| ▸ | GRM6 | O15303 | 2/20 | 0.55 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.55 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.55 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.55 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.55 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.55 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.55 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.55 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2263983 | 1.00 | GSR (0.55) | GSRGRM8GRM6GRM7GRM4 | |
| SCHEMBL359142 | 1.00 | GSR (0.55) | GSRGRM8GRM6GRM7GRM4 | |
| SCHEMBL29741400 | 0.94 | GSR (0.57) | GSRGRM8GRM6GRM7GRM4 | |
| SCHEMBL29485083 | 0.90 | GSR (0.61) | GSRGRM8GRM6GRM7GRM4 | |
| SCHEMBL28717409 | 0.87 | ARG2 (0.50) | GSRGRM8GRM6GRM7GRM4 | |
| SCHEMBL2548650 | 0.87 | GSR (0.53) | GSRGRM8GRM6GRM7GRM4 | |
| SCHEMBL43621 | 0.87 | GSR (0.53) | GSRGRM8GRM6GRM7GRM4 | |
| Water SCHEMBL380639 | 0.85 | GSR (0.52) | GSRGRM8GRM6GRM7GRM4 | |
| SCHEMBL448753 | 0.83 | GSR (0.77) | GSRCYP1A2ARG2ARG1ALOX15 | |
| SCHEMBL31612943 | 0.83 | GSR (0.53) | GSRGRM8GRM6GRM7GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3847257-A1 | ASPARAGINE SYNTHETASE INHIBITORS AND USES THEREOF | Ospedale San Raffaele S.r.l. (IT) | 2021-07-14 | — | — | EP | disclosed |
| CN-112703200-A | Antibodies against end products of saccharification and uses thereof | 布鲁姆科技株式会社 | 2021-04-23 | — | — | CN | disclosed |
| EP-3720290-A1 | PET FOOD COMPOSITION AND METHOD OF MAKING PET FOOD COMPOSITION COMPRISING ENHANCED LEVELS OF RESISTANT STARCH | Hill's Pet Nutrition, Inc. (US) | 2020-10-14 | — | — | EP | disclosed |
| US-20200247846-A1 | INHIBITION OF OXIDATIVE STRESS, GLYCATION, AND PROTEIN CROSSLINKING | UNIV COLORADO REGENTS (US) | 2020-08-06 | — | — | US | disclosed |
| EP-3668521-A1 | INHIBITION OF OXIDATIVE STRESS, GLYCATION, AND PROTEIN CROSSLINKING | The Regents of the University of Colorado, a body corporate (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2020071258-A1 | PROTEIN GLYCATION SUPPRESSANT | 味の素株式会社 | 2020-04-09 | — | — | WO | disclosed |
| EP-3237366-B1 | 1-(3,4-DISUBSTITUTED)PHENYL-2-(3,4-DISUBSTITUTED)PHENYLETHANE COMPOUNDS AND USE THEREOF | OREAL (FR) | 2019-09-11 | — | — | EP | disclosed |
| US-10357440-B2 | Composition comprising at least one 2-(3,4-disubstituted)phenyl-1-(3,4-disubstituted)phenyl-1-hydroxyethane for preventing and/or treating the signs of ageing of the skin | L'OREAL (FR) | 2019-07-23 | — | — | US | disclosed |
| WO-2019112562-A1 | PET FOOD COMPOSITION AND METHOD OF MAKING PET FOOD COMPOSITION COMPRISING ENHANCED LEVELS OF RESISTANT STARCH | HILL'S PET NUTRITION, INC. (US) | 2019-06-13 | — | — | WO | disclosed |
| WO-2019036336-A1 | INHIBITION OF OXIDATIVE STRESS, GLYCATION, AND PROTEIN CROSSLINKING | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2019-02-21 | — | — | WO | disclosed |
| US-20170367952-A1 | 1-(3,4-DISUBSTITUTED)PHENYL-2-(3,4-DISUBSTITUTED)PHENYLETHANE COMPOUNDS AND USE THEREOF | L'OREAL (FR) | 2017-12-28 | — | — | US | disclosed |
| US-8445440-B2 | Dimeric IAP inhibitors | NOVARTIS AG (CH) | 2013-05-21 | — | — | US | disclosed |
| EP-2539333-A1 | DIMERIC IAP INHIBITORS | Novartis AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011104266-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-09-01 | — | — | WO | disclosed |
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247846-A1 | INHIBITION OF OXIDATIVE STRESS, GLYCATION, AND PROTEIN CROSSLINKING | AGER, CRYAB, CRYAA | GSR 26/4885GRM8 4129/4885GRM6 3267/4885 |
| US-10357440-B2 | Composition comprising at least one 2-(3,4-disubstituted)phenyl-1-(3,4-disubstituted)phenyl-1-hydroxyethane for preventing and/or treating the signs of ageing of the skin | TYR, CYP8B1, POT1 | GSR 521/4885GRM8 4661/4885GRM6 4789/4885 |
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | XIAP, BIRC5, BIRC2 | GSR 4037/4885GRM8 3858/4885GRM6 3010/4885 |
| US-20170367952-A1 | 1-(3,4-DISUBSTITUTED)PHENYL-2-(3,4-DISUBSTITUTED)PHENYLETHANE COMPOUNDS AND USE THEREOF | TYR, PAH, ACOX1 | GSR 416/4885GRM8 4829/4885GRM6 4799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.