Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948039 | 0.83 | LMNA (0.53) | KMT2ALMNASYKTBXAS1MAOB | |
| SCHEMBL11062489 | 0.77 | TBXAS1 (0.69) | KMT2ALMNATBXAS1NPC1RAB9A | |
| SCHEMBL6859304 | 0.75 | KMT2A (1.00) | KMT2ALMNATSHRSMN1; SMN2RAB9A | |
| SCHEMBL1772554 | 0.75 | HRH3 (0.44) | LMNASMN1; SMN2NPC1RAB9AHRH3 | |
| SCHEMBL28172483 | 0.75 | RAB9A (0.50) | LMNASYKSMN1; SMN2RAB9A | |
| SCHEMBL3048473 | 0.74 | ALDH1A1 (0.50) | KMT2AVNN1HRH3L3MBTL1 | |
| SCHEMBL27665378 | 0.73 | KMT2A (0.53) | KMT2ALMNATSHRSMN1; SMN2NPC1 | |
| SCHEMBL24287923 | 0.72 | KDM4E (0.39) | KMT2ALMNATSHRTBXAS1SMN1; SMN2 | |
| SCHEMBL1521573 | 0.71 | HSP90AA1 (0.43) | TSHRVNN1HDAC3HDAC1HDAC2 | |
| SCHEMBL4086758 | 0.71 | IDO1 (0.44) | KMT2ALMNATSHRSYKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116858-B1 | AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2020-11-11 | — | — | EP | disclosed |