Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 8/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22641675 | 0.91 | MAPT (0.47) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL22641730 | 0.91 | MAPT (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL22579295 | 0.90 | HDAC1 (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL22641747 | 0.83 | MAPT (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL22579255 | 0.82 | MAPT (0.42) | HDAC4HDAC1MAPTKDM4ELMNA | |
| SCHEMBL8321030 | 0.80 | HDAC1 (0.44) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL22579296 | 0.79 | MAOB (0.43) | MAPTKDM4EMGLLESR1 | |
| SCHEMBL1579763 | 0.79 | MGLL (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1579761 | 0.79 | MGLL (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL38654486 | 0.79 | TRPM8 (0.41) | HDAC3HDAC4HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3736266-A1 | COMPOUND SIMULTANEOUSLY INHIBITING LSD1 AND HDAC TARGETS AND APPLICATION THEREOF | Peking University Shenzhen Graduate School (CN) | 2020-11-11 | — | — | EP | disclosed |