Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22641675 | 0.94 | MAPT (0.47) | MAPTKDM4ELMNAKMT2AMEN1 | |
| SCHEMBL22641632 | 0.91 | HDAC3 (0.50) | MAPTKDM4ELMNAHDAC3HDAC4 | |
| SCHEMBL22579255 | 0.88 | MAPT (0.42) | MAPTKDM4ELMNAALDH1A1KMT2A | |
| SCHEMBL22641747 | 0.83 | MAPT (0.39) | MAPTKDM4ELMNAALDH1A1KMT2A | |
| SCHEMBL22579296 | 0.82 | MAOB (0.43) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL23911848 | 0.81 | AURKA (0.40) | MAPTKDM4ELMNAALDH1A1KMT2A | |
| SCHEMBL1579761 | 0.81 | MGLL (0.43) | KDM4EALDH1A1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL38654486 | 0.81 | TRPM8 (0.41) | MAPTKDM4ELMNAALDH1A1KMT2A | |
| SCHEMBL1579763 | 0.81 | MGLL (0.43) | KDM4EALDH1A1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL26186289 | 0.81 | MGLL (0.41) | MAPTKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3736266-A1 | COMPOUND SIMULTANEOUSLY INHIBITING LSD1 AND HDAC TARGETS AND APPLICATION THEREOF | Peking University Shenzhen Graduate School (CN) | 2020-11-11 | — | — | EP | disclosed |