Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15553344 | 0.79 | BRAF (0.58) | RECQLSMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL6528742 | 0.79 | SMN1; SMN2 (0.52) | RECQLSMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL26633294 | 0.77 | ADORA3 (0.51) | RECQLSMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL8518362 | 0.77 | CYP1A2 (0.48) | RECQLSMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL13763337 | 0.76 | TRPV1 (0.56) | SMN1; SMN2MAPTHPGDKDM4EMEN1 | |
| SCHEMBL23518443 | 0.75 | RAB9A (0.76) | SMN1; SMN2MAPTNPSR1HPGDADORA2A | |
| SCHEMBL19668020 | 0.74 | RAB9A (0.51) | RECQLSMN1; SMN2ALDH1A1MAPTADORA2A | |
| SCHEMBL23518425 | 0.74 | HPGD (0.63) | SMN1; SMN2ALDH1A1MAPTNPSR1HPGD | |
| SCHEMBL19678085 | 0.72 | KIT (0.56) | SMN1; SMN2ALDH1A1MAPTNPSR1KDM4E | |
| SCHEMBL12233658 | 0.72 | KIF11 (0.44) | RECQLSMN1; SMN2ALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200354367-A1 | COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200354367-A1 | COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | XBP1, RNASE1, ERN1 | RECQL 1589/4885SMN1; SMN2 51/4885ALDH1A1 2682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.