Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.46 |
| ▸ | CCND1 | P24385 | 8/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 15/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | CCND3 | P30281 | 5/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650467 | 0.95 | CDK4 (0.49) | CDK4CCND1CDK6TYK2JAK2 | |
| SCHEMBL22650591 | 0.86 | CDK6 (0.48) | CDK4CCND1CDK6TYK2JAK2 | |
| SCHEMBL22650928 | 0.84 | CDK6 (0.50) | CDK4CCND1CDK6PIM1CCND3 | |
| SCHEMBL22650468 | 0.83 | CDK6 (0.41) | CDK4CCND1CDK6TYK2JAK2 | |
| SCHEMBL22650401 | 0.76 | NTRK1 (0.46) | CDK4CDK6JAK2JAK1JAK3 | |
| SCHEMBL22650487 | 0.75 | CDK4 (0.42) | CDK4CDK6TYK2JAK2JAK1 | |
| SCHEMBL22650475 | 0.75 | CDK6 (0.58) | CDK4CCND1CDK6PIM1CCND3 | |
| SCHEMBL22650845 | 0.74 | CDK6 (0.48) | CDK4CCND1CDK6CCND3CCNA2 | |
| SCHEMBL22650945 | 0.73 | CDK6 (0.60) | CDK4CCND1CDK6PIM1CCND3 | |
| SCHEMBL22650846 | 0.73 | CDK4 (0.42) | CDK4CCND1CDK6TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |