Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.34 |
| ▸ | CDK2 | P24941 | 6/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.34 |
| ▸ | ABL1 | P00519 | 4/20 | 0.34 |
| ▸ | LYN | P07948 | 3/20 | 0.34 |
| ▸ | BCR | P11274 | 2/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | ARAF | P10398 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650597 | 0.89 | EGFR (0.37) | EGFRJAK2BRD4JAK1BRD2 | |
| SCHEMBL22650522 | 0.84 | F10 (0.37) | EGFRCCNA2CDK2CCNA1CDK4 | |
| SCHEMBL22650428 | 0.83 | CDK4 (0.35) | EGFRBRD4CCNA2CDK2CCNA1 | |
| SCHEMBL22650421 | 0.78 | JAK2 (0.38) | EGFRJAK2BRD4JAK1JAK3 | |
| SCHEMBL22650433 | 0.77 | EGFR (0.36) | EGFRCDK4CCND3GSK3B | |
| SCHEMBL22650901 | 0.77 | CDK4 (0.45) | CCNA2CDK2CCNA1CDK4CCND3 | |
| SCHEMBL22650823 | 0.77 | CDK4 (0.45) | CCNA2CDK2CCNA1CDK4CCND3 | |
| SCHEMBL22650370 | 0.76 | CDK4 (0.35) | CCNA2CDK2CCNA1CDK4CCND3 | |
| SCHEMBL22650541 | 0.75 | EGFR (0.36) | EGFRCCNA2CDK2CCNA1CDK4 | |
| SCHEMBL22650922 | 0.73 | F10 (0.38) | EGFRJAK2JAK1JAK3MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |