Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 3/20 | 0.35 |
| ▸ | CCND3 | P30281 | 3/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 5/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | LDLR | P01130 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650702 | 0.89 | JAK2 (0.39) | EGFRBTKCCNA2CDK2CCNA1 | |
| SCHEMBL22650519 | 0.89 | EGFR (0.36) | CDK4CCND3CDK6EGFRCCNA2 | |
| SCHEMBL22650521 | 0.88 | CDK4 (0.40) | CDK4CCND3CDK6CCNA2CDK1 | |
| SCHEMBL22650598 | 0.83 | EGFR (0.37) | CDK4CCND3EGFRCCNA2CDK2 | |
| SCHEMBL22650522 | 0.83 | F10 (0.37) | CDK4CCND3CDK6EGFRBTK | |
| SCHEMBL22650523 | 0.79 | EGFR (0.42) | EGFRCDK2CDK5CDK5R1IGF1R | |
| SCHEMBL22650427 | 0.79 | EGFR (0.36) | CDK4CCND3CDK6EGFRBTK | |
| SCHEMBL22650527 | 0.78 | CDK4 (0.40) | CDK4CCND3CDK6BTKCCNA2 | |
| SCHEMBL22650709 | 0.77 | JAK2 (0.39) | CDK4CDK1PDGFRBABL1BCR | |
| SCHEMBL22650532 | 0.74 | EGFR (0.36) | CDK4CCND3CDK6EGFRPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |