Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 8/20 | 0.38 |
| ▸ | CDK2 | P24941 | 6/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650519 | 0.91 | EGFR (0.36) | EGFRMAPK8PIK3CGCAMKK2 | |
| SCHEMBL22650709 | 0.88 | JAK2 (0.39) | CDK5CDK5R1JAK2 | |
| SCHEMBL22650427 | 0.82 | EGFR (0.36) | EGFRIGF1RJAK2 | |
| SCHEMBL22650707 | 0.80 | JAK2 (0.39) | CAMKK2JAK2 | |
| SCHEMBL22650428 | 0.79 | CDK4 (0.35) | EGFRIGF1RCDK2CDK5CDK5R1 | |
| SCHEMBL22650419 | 0.78 | JAK2 (0.38) | JAK2 | |
| SCHEMBL22650450 | 0.78 | CDK4 (0.41) | GSK3BCDK2 | |
| SCHEMBL22650795 | 0.77 | CDK4 (0.41) | GSK3BCDK2 | |
| SCHEMBL22650847 | 0.77 | JAK2 (0.39) | CDK2JAK2 | |
| SCHEMBL22650702 | 0.77 | JAK2 (0.39) | EGFRCDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |