Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 2/20 | 0.32 |
| ▸ | CCND1 | P24385 | 2/20 | 0.32 |
| ▸ | CCND3 | P30281 | 2/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.31 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650624 | 0.93 | EGFR (0.34) | EGFRCCND3CDK6 | |
| SCHEMBL22650777 | 0.89 | ACVR1 (0.35) | TTKEGFRCDK4CDK6MAPK1 | |
| SCHEMBL22650576 | 0.88 | CDK6 (0.38) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22650513 | 0.79 | CDK4 (0.36) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22650455 | 0.76 | PIK3CG (0.35) | TTKCDK4CCND1CDK6PIK3CG | |
| SCHEMBL22650541 | 0.75 | EGFR (0.36) | EGFRCDK4CCND1ALK | |
| SCHEMBL22650532 | 0.75 | EGFR (0.36) | EGFRCDK4CCND1CCND3CDK6 | |
| SCHEMBL22650875 | 0.74 | TYK2 (0.44) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22650579 | 0.74 | CDK4 (0.48) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22650778 | 0.73 | CDK4 (0.42) | CDK4CCND1CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |