Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650755 | 0.92 | CDK4 (0.42) | CDK1CCNB1CDK4CCND1CDK6 | |
| SCHEMBL22650455 | 0.89 | PIK3CG (0.35) | JAK2CDK1CCNB1CDK4CCND1 | |
| SCHEMBL22650715 | 0.89 | CDK6 (0.35) | JAK2CDK1CCNB1CDK4CCND1 | |
| SCHEMBL22650526 | 0.84 | MAP4K1 (0.44) | JAK2JAK3CDK1CCNB1CDK4 | |
| SCHEMBL22650422 | 0.82 | CDK1 (0.41) | JAK2JAK3CDK1CCNB1CDK4 | |
| SCHEMBL22650421 | 0.81 | JAK2 (0.38) | JAK2JAK3CDK1CCNB1CDK4 | |
| SCHEMBL22650709 | 0.81 | JAK2 (0.39) | JAK2JAK3CDK1CCNB1CDK4 | |
| SCHEMBL22650705 | 0.80 | CDK6 (0.39) | CDK1CCNB1CDK4CCND1CDK6 | |
| SCHEMBL22650707 | 0.79 | JAK2 (0.39) | JAK2JAK3CDK1CCNB1CDK4 | |
| SCHEMBL22650847 | 0.79 | JAK2 (0.39) | JAK2JAK3CDK1CCNB1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |