Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Edetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | EYA2 | O00167 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Edetic Acid SCHEMBL144663 | 0.97 | KDM4E (0.68) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL18983963 | 0.97 | KDM4E (0.68) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL770659 | 0.97 | KDM4E (0.68) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL5729 | 0.97 | KDM4E (0.68) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL243998 | 0.94 | KDM4E (0.73) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Pentetic Acid SCHEMBL2274186 | 0.94 | KDM4E (0.73) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL413600 | 0.94 | KDM4E (0.65) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL8933697 | 0.94 | KDM4E (0.65) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL5485760 | 0.94 | KDM4E (0.73) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL41639 | 0.94 | KDM4E (0.73) | KDM4EALOX15MAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113797359-B | bTiO mediated by IGF 1receptor 2 Construction method and performance verification method of pancreatic cancer diagnosis and treatment nano probe | 宁波大学医学院附属医院 | 2022-12-23 | — | — | CN | claimed |
| US-20210060060-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LUNG EMPHYSEMA AND OTHER FORMS OF COPD | EMPHYSEMA SOLUTIONS BV (NL) | 2021-03-04 | — | — | US | claimed |
| EP-3737364-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LUNG EMPHYSEMA AND OTHER FORMS OF COPD | Emphysema Solutions BV (NL) | 2020-11-18 | — | — | EP | claimed |
| CN-111615385-A | Compositions and methods for treating emphysema and other forms of COPD | 肺气肿解决方案私人有限公司 | 2020-09-01 | — | — | CN | claimed |
| CN-119716047-A | Method for detecting anti-cytomegalovirus neutralizing antibodies | 变异生物技术公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119051117-A | Power distribution network weak link identification method and system containing large-scale distributed energy access under typhoon disaster | 广西电网有限责任公司电力科学研究院 | 2024-11-29 | — | — | CN | disclosed |
| CN-118526605-A | Up-conversion nano-composite and preparation method and application thereof | 华南师范大学 | 2024-08-23 | — | — | CN | disclosed |
| WO-2024129041-A1 | A CARD TEST FOR THE DIAGNOSIS OF THE MUSHROOM TOXIN GYROMITRIN AND ITS METABOLITES | T.C ANKARA UNIVERSITESI REKTORLUGU (TR) | 2024-06-20 | — | — | WO | disclosed |
| WO-2024129040-A1 | A CARD TEST FOR THE HALLUCINOGENIC PSILOCYBIN MOLECULE THAT ALLOWS THE DIAGNOSIS OF TOXIC MUSHROOMS AND MUSHROOM TOXICITIES | T.C ANKARA UNIVERSITESI REKTORLUGU (TR) | 2024-06-20 | — | — | WO | disclosed |
| CN-117700548-A | anti-CD 33 antibodies and methods of use thereof | 艾利妥 | 2024-03-15 | — | — | CN | disclosed |
| CN-110662765-B | anti-CD 33 antibodies and methods of use thereof | 艾利妥 | 2023-09-29 | — | — | CN | disclosed |
| CN-112384283-B | Therapeutic heterocyclic compounds | 吉利德科学公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-114344449-A | Application of histaminin 1 polypeptide in preparation of composite material for promoting repair of large-area skin defect | 杭州彗搏科技有限公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-114173821-A | Methods and compositions for restoring STMN2 levels | 哈佛学院校长同事会 | 2022-03-11 | — | — | CN | disclosed |
| CN-107073169-B | Composite material for tissue repair | 约翰·霍普金斯大学技术创业公司 | 2022-03-08 | — | — | CN | disclosed |
| CN-108474752-B | System and method for detecting syringe seal defects | W.L.戈尔及同仁股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-113980071-A | Salidroside derivatives and application thereof | 重庆大学 | 2022-01-28 | — | — | CN | disclosed |
| US-20210060060-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LUNG EMPHYSEMA AND OTHER FORMS OF COPD | EMPHYSEMA SOLUTIONS BV (NL) | 2021-03-04 | — | — | US | disclosed |
| EP-3737364-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LUNG EMPHYSEMA AND OTHER FORMS OF COPD | Emphysema Solutions BV (NL) | 2020-11-18 | — | — | EP | disclosed |
| CN-111615385-A | Compositions and methods for treating emphysema and other forms of COPD | 肺气肿解决方案私人有限公司 | 2020-09-01 | — | — | CN | disclosed |