Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Edetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | EYA2 | O00167 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Edetic Acid SCHEMBL770659 | 1.00 | KDM4E (0.68) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL15103670 | 0.97 | KDM4E (0.65) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL16004809 | 0.97 | KDM4E (0.73) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL1535275 | 0.97 | KDM4E (0.65) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL3491246 | 0.97 | KDM4E (0.65) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL41639 | 0.97 | KDM4E (0.73) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL5485760 | 0.97 | KDM4E (0.73) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Pentetic Acid SCHEMBL1477452 | 0.97 | KDM4E (0.73) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL22654038 | 0.97 | KDM4E (0.65) | KDM4EALOX15MAPTSMN1; SMN2TDP1 | |
| Edetic Acid SCHEMBL14860165 | 0.97 | KDM4E (0.65) | KDM4EALOX15MAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 17810 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075470-A | Application of oridonin in preparation of external preparation for treating skin scald | — | 2026-05-26 | — | — | CN | claimed |
| CN-122005353-A | Oil-in-water microsphere for wrapping cosmetic active | 上海观辰悦彩生物科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4716693-A2 | PHARMACEUTICAL COMPOSITIONS FOR ANTIBODIES AND MAKING AND USING THE SAME | INVETX, INC. (US) | 2026-04-01 | — | — | EP | claimed |
| US-12303592-B2 | Formulations for parenteral delivery of compounds and uses thereof | WYETH, LLC (US) | 2025-05-20 | — | — | US | claimed |
| CN-119977696-A | Water and fertilizer retention composition suitable for sandy soil and preparation method thereof | 新洋丰农业科技股份有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119950485-A | Application of oridonin in preparation of external preparation for treating atopic dermatitis | 南方医科大学 | 2025-05-09 | — | — | CN | claimed |
| WO-2024243322-A9 | PHARMACEUTICAL COMPOSITIONS FOR ANTIBODIES AND MAKING AND USING THE SAME | INVETX, INC. (US) | 2025-03-27 | — | — | WO | claimed |
| EP-3665172-B1 | COMPOUNDS AS POTENTIAL DYE MOLECULES | Lleaf Pty Ltd (AU) | 2025-03-19 | — | — | EP | claimed |
| US-20250082787-A1 | ALGINIC ACID-BASED INJECTABLE HYDROGEL SYSTEM | NATIONAL CANCER CENTER (KR) | 2025-03-13 | — | — | US | claimed |
| US-20250064759-A1 | CONTAINER COMPRISING A LISDEXAMFETAMINE CONTAINING ORAL SOLUTION | LABOMED PHARMACEUTICAL COMPANY S.A. (GR) | 2025-02-27 | — | — | US | claimed |
| WO-1998020836-A2 | PURE BIOLOGICALLY ACTIVE COLISTIN, ITS COMPONENTS AND A COLISTIN FORMULATION FOR TREATMENT OF PULMONARY INFECTIONS | PATHOGENESIS CORPORATION (US) | 1998-05-22 | — | — | WO | claimed |
| EP-0673507-B1 | LOW OXYGEN TRANSMISSION IMAGING SYSTEM | GRACE W R & CO (US) | 1997-06-18 | — | — | EP | claimed |
| EP-0554634-B1 | Stabilized pharmaceutical composition comprising non-glycosylated, reduced, recombinant human IL-2 and process to prepare it | ROUSSEL UCLAF (FR) | 1996-03-27 | — | — | EP | claimed |
| EP-0673507-A1 | LOW OXYGEN TRANSMISSION IMAGING SYSTEM. | GRACE W R & CO (US) | 1995-09-27 | — | — | EP | claimed |
| US-5340574-A | Lymphokine in mixture with citric acid, mannitol and preservative | ROUSSEL-UCLAF (FR) | 1994-08-23 | — | — | US | claimed |
| CN-1088729-A | \" Guolieling \" chemical for preventing fruit or melon from dehiscing | YANG XIZHANG (CN) | 1994-07-06 | — | — | CN | claimed |
| WO-1994014059-A1 | LOW OXYGEN TRANSMISSION IMAGING SYSTEM | W. R. GRACE & CO.-CONN. (US) | 1994-06-23 | — | — | WO | claimed |
| US-5316949-A | Using a fluorescent redox indicator | W. R. GRACE & CO.-CONN. (US) | 1994-05-31 | — | — | US | claimed |
| US-5229270-A | Quantitative analysis for chloride by forming a chelate with calcium ion, deactivated alpha-amylase, a calcium chelate and an activity measuring substance | KANTO KAGAKU KABUSHIKI KAISHA (JP) | 1993-07-20 | — | — | US | claimed |
| US-4465629-A | Method to increase color fastness of stabilized aloe vera | MAUGHAN REX G | 1984-08-14 | — | — | US | claimed |