SCHEMBL22654073

SCHEMBL22654073

Cc1nn(C)c(=O)c(-c2c(F)ccc(Cl)c2C#Cc2ccccc2)c1O

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 18/20 0.38
CDK8 P49336 1/20 0.35
ACVR1 Q04771 1/20 0.35
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30389348 0.92 NR3C1 (0.34) GRM4
SCHEMBL25180896 0.92 NR3C1 (0.34) GRM4
SCHEMBL28444233 0.84 GRM4 (0.36) GRM4CDK8ACVR1
SCHEMBL22654078 0.84 GAA (0.34) GRM4CDK8ACVR1LMNA
SCHEMBL22654076 0.83 GRM4 (0.35) GRM4CDK8ACVR1LMNA
SCHEMBL29263842 0.77 GRM4 (0.33) GRM4
SCHEMBL22031802 0.77 KMT2A (0.36) CDK8ACVR1LMNA
SCHEMBL29457662 0.77 KMT2A (0.36) CDK8ACVR1LMNA
SCHEMBL2484646 0.77 MAPT (0.44) CDK8ACVR1LMNA
SCHEMBL22031792 0.77 CASR (0.40) CDK8ACVR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3737667-B1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2024-04-03 EP disclosed
CN-111566094-B herbicidal compounds 先正达参股股份有限公司 2023-10-13 CN disclosed
US-20210009530-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-01-14 US disclosed
US-20210009530-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-01-14 US disclosed
EP-3737667-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2020-11-18 EP disclosed
CN-111566094-A Herbicidal compounds 先正达参股股份有限公司 2020-08-21 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210009530-A1 HERBICIDAL COMPOUNDS DDT, HPD, PGD GRM4 3208/4885CDK8 2523/4885ACVR1 1778/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.